Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier
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Interferon-λ signaling tightens the blood-brain barrier and limits the ability of West Nile virus to infect the central nervous system in mice.
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Interferons produced during viral infections, such as West Nile virus, protect blood-brain barrier integrity to virions by restricting their entry into brain parenchyma.
“Interferons produced during viral infections, e.g., West Nile virus, protect the BBB integrity to virions by restricting their entry into brain parenchyma (131, 348).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [348]
During West Nile virus (WNV) infection, type I and type III interferon signaling promotes tightening of the BBB in CNS vascular endothelial cells, restricting virus from accessing the CNS.
“During West Nile virus (WNV) infection, type I and type III interferon signaling promotes tightening of the BBB in CNS vascular endothelial cells, restricting virus from accessing the CNS (150, 151).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [151]
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References 39 · Cited by 234
- Authors
- Lazear, H. M., Daniels, B. P., Pinto, A. K., Huang, A. C., Vick, S. C., Doyle, S. E., Gale, M., Klein, R. S., & Diamond, M. S.
- Affiliations
- Washington University in St. Louis (US)
- University of Washington (US)
- Bristol-Myers Squibb (United States) (US)
- Corresponding author
- Lazear, Helen M.
- Daniels, Brian P.
- Klein, Robyn S.
- Diamond, Michael S.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-04-22
- Volume
- 7
- Issue
- 284
- Pages
- 284ra59-284ra59
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4435724
- OpenAlex
- W2034310945
- Cited by
- 234
- References
- 39
- Citations by year
- 2026: 21 · 2025: 11 · 2024: 12 · 2023: 13 · 2022: 23 · 2021: 22 · 2020: 24 · 2019: 24 · 2018: 26 · 2017: 32 · 2016: 14 · 2015: 12
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- NSF (DGE-1143954)
- NIH (U19 AI083019, AI083019-02S1, T32-AI007172, R01 AI074973, R01 NS052632, F31-NS07866-01)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Keywords
- interferon lambda, West Nile virus, blood-brain barrier permeability, neuroinvasion, interferon lambda receptor 1, tight junctions, flavivirus encephalitis, brain microvascular endothelial cells, transendothelial electrical resistance, antiviral immunity
- MeSH terms
- Animals, Antiviral Agents, Blood-Brain Barrier, Brain, Cell Line, Gene Expression Regulation, Humans, Immunity, Cellular, Interferons, Macrophages, Mice, Inbred C57BL, Microcirculation, Neurons, Permeability, Recombinant Proteins, Virus Replication, West Nile Fever, West Nile virus, Signal Transduction, Keratinocytes, Electric Impedance, Receptors, Interferon, Receptors, Cytokine, Mice, Knockout, Microscopy, Confocal, Mice, Adaptive Immunity
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