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SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma
Open accessAbstract
SLC7A11, the catalytic subunit of the cystine/glutamate antiporter, System x c − (SXC), is up-regulated in a subpopulation of patient gliomas, where it is responsible for excitotoxic glutamate release, accelerated tumor growth, and tumor-associated seizures.
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“The enhanced glutamatergic drive is the result of glutamate (Glu) being assiduously released from gliomas via system Xc transporter (SXC) encoded by the SLC7A11 gene that is upregulated in about 54% of glioma patients4.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [4]
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“The cellular and molecular changes underlying tumor-associated epilepsy collectively point to a decrease in GABAergic and increase in glutamatergic transmission as the major contributors3–6.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [4]
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Self-citation
Metadata
- Authors
- Robert, S. M., Buckingham, S. C., Campbell, S. L., Robel, S., Holt, K. T., Ogunrinu-Babarinde, T., Warren, P. P., White, D. M., Reid, M. A., Eschbacher, J. M., Berens, M. E., Lahti, A. C., Nabors, L. B., & Sontheimer, H.
- Affiliations
- University of Alabama at Birmingham (US)
- Department of Neurobiology, Center for Glial Biology in Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Translational Genomics Research Institute (US)
- Division of Neuro-oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Corresponding author
- Sontheimer, Harald
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-05-27
- Volume
- 7
- Issue
- 289
- Pages
- 289ra86-289ra86
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4503260
- OpenAlex
- W2099513242
- Cited by
- 301
- References
- 61
- Citations by year
- 2026: 29 · 2025: 31 · 2024: 32 · 2023: 34 · 2022: 26 · 2021: 32 · 2020: 22 · 2019: 26 · 2018: 22 · 2017: 19 · 2016: 23 · 2015: 5
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (5R01NS052634, 2RO1NS036692, 5RO1NS031234, 1F31NS074597, 1R01NS082851, 5TL1RR025775-04, 2T32NS048039, T32GM008361, T32GM008362)
- Ben & Catherine Ivy Foundation
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- SLC7A11, system xc-, high-grade glioma, seizures, glutamate release, glutathione synthesis, tumor growth, overall survival, sulfasalazine, magnetic resonance spectroscopy, prognostic factors
- MeSH terms
- Edema, Glioma, Glutamates, Humans, Neurons, Neurotoxins, Seizures, Survival Analysis, Genomics, Amino Acid Transport System y+
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