Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma
Open accessAbstract
A secreted hookworm protein in recombinant form acts on dendritic cells to drive the expansion and mucosal homing of regulatory T cells that protect against airway inflammation in mice, and also dampens human dendritic cell and T cell activation.
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The fully foreign hookworm product AIP-2 is minimally immunogenic in vivo.
“the fully foreign hookworm product AIP-2 is minimally immunogenic in vivo (Navarro et al., 2016).”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Navarro et al., 2016
Cites
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054 · see citing works
Global asthma prevalence in adults: findings from the cross-sectional world health survey
To, T., Stanojevic, S., Moores, G., Gershon, A. S., Bateman, E. D., Cruz, A. A., & Boulet, L.-P. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-204 · Cited by 1,521 · see citing works
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Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
Maizels, R. M., Smits, H. H., & McSorley, H. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.016 · Cited by 435 · see citing works
Protozoan‐Derived Cytokine‐Transgenic Macrophages Reverse Hepatic Fibrosis
Chen, Y., Wang, J., Zhou, N., Fang, Q., Cai, H., Du, Z., An, R., Liu, D., Chen, X., Wang, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202308750 · Cited by 12 · see citing works
- Authors
- Navarro, S., Pickering, D. A., Ferreira, I. B., Jones, L., Ryan, S., Troy, S., Leech, A., Hotez, P. J., Zhan, B., Laha, T., Prentice, R., Sparwasser, T., Croese, J., Engwerda, C. R., Upham, J. W., Julia, V., Giacomin, P. R., & Loukas, A.
- Affiliations
- Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
- Australian Institute of Tropical Health and Medicine (AU)
- Baylor College of Medicine (US)
- Khon Kaen University (TH)
- Royal Brisbane and Women's Hospital (AU)
- Center for Experimental and Clinical Infection Research (DE)
- QIMR Berghofer Medical Research Institute (AU)
- The University of Queensland (AU)
- CNRS UMR7275, INSERM U1080, Université de Nice Sophia Antipolis, Nice, France.
- Corresponding author
- Loukas, Alex
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2016-10-26
- Volume
- 8
- Issue
- 362
- Pages
- 362ra143-362ra143
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2541194853
- Cited by
- 139
- References
- 2
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 12 · 2023: 9 · 2022: 12 · 2021: 15 · 2020: 23 · 2019: 13 · 2018: 25 · 2017: 16 · 2016: 4
- FWCI
- 19.94
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline at James Cook University (James Cook University) (submittedVersion)
- Griffith Research Online (submittedVersion, other-oa)
- Funders
- National Health and Medical Research Council of Australia (1037034)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- hookworm, regulatory T cells, asthma, dendritic cells, mucosal homing, airway inflammation, T cell activation, immunomodulation, helminth therapy
- MeSH terms
- Adult, Ancylostomatoidea, Animals, Asthma, Dendritic Cells, Disease Models, Animal, Female, Humans, Hypersensitivity, Immunoglobulin E, Inflammation, Male, Mucous Membrane, Recombinant Proteins, Antigens, CD, Helminth Proteins, Prevalence, Cytokines, Integrin alpha Chains, Pyroglyphidae, Cell Proliferation, T-Lymphocytes, Regulatory, Mice
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