Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury
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CSF sTREM2 increases in early stages of autosomal dominant Alzheimer’s disease, but the increase occurs after changes in Aβ and tau.
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Levels of soluble TREM2 (sTREM2) have been shown to increase five years before symptom onset in autosomal dominant forms of AD.
“For example, the levels of soluble TREM2 (sTREM2) have been shown to increase five years before symptom onset in autosomal dominant forms of AD [212].”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [212]
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References 68 · Cited by 272
- Authors
- Suárez-Calvet, M., Araque Caballero, M. Á., Kleinberger, G., Bateman, R. J., Fagan, A. M., Morris, J. C., Levin, J., Danek, A., Ewers, M., Haass, C., & for the Dominantly Inherited Alzheimer Network
- Affiliations
- German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
- Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.
- Munich Cluster for Systems Neurology (DE)
- Washington University in St. Louis (US)
- German Center for Neurodegenerative Diseases (DE)
- Institut für Schlaganfall- und Demenzforschung (DE)
- Corresponding author
- Ewers, Michael
- Haass, Christian
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2016-12-14
- Volume
- 8
- Issue
- 369
- Pages
- 369ra178-369ra178
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5385711
- OpenAlex
- W2567168289
- Cited by
- 272
- References
- 68
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 29 · 2023: 18 · 2022: 34 · 2021: 32 · 2020: 36 · 2019: 27 · 2018: 31 · 2017: 23
- FWCI
- 14.79
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DZNE Pub (submittedVersion)
- Funders
- European Research Council
- European Union’s Seventh Framework Program (FP7/2007–2013)
- Deutsche Forschungsgemeinschaft
- ERC (321366-amyloid, PCIG12-GA-2012-334259)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- soluble TREM2, cerebrospinal fluid biomarkers, autosomal dominant Alzheimer's disease, microglial activation, amyloid deposition, neuronal injury, neurodegeneration, cognitive decline, preclinical Alzheimer's disease, innate immunity
- MeSH terms
- Adult, Alzheimer Disease, Amyloidosis, Apolipoproteins E, Brain, DNA Mutational Analysis, Female, Genes, Dominant, Heterozygote, Humans, Immunity, Innate, Male, Membrane Glycoproteins, Middle Aged, Mutation, Neurons, Receptors, Immunologic, Time Factors, Cohort Studies, Biomarkers, Case-Control Studies, Amyloid beta-Peptides, tau Proteins, Microglia, Disease Progression, Siblings
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