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Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system
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A handheld and biocompatible mass spectrometry system provides nondestructive molecular diagnosis of cancer tissue samples.
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“Perception-based approaches have been used to classify various disease conditions on the basis of different patterns in methylation of DNA sequencing13, volatile organic compounds using electronic noses14, small metabolites using mass spectrometry15, and image analysis of pathology, computerized tomography scans and magnetic resonance imaging data16,17.”
From Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning (2022) · cites this paper as [15]
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Metadata
- Authors
- Zhang, J., Rector, J., Lin, J. Q., Young, J. H., Sans, M., Katta, N., Giese, N., Yu, W., Nagi, C., Suliburk, J., Liu, J., Bensussan, A., DeHoog, R. J., Garza, K. Y., Ludolph, B., Sorace, A. G., Syed, A., Zahedivash, A., Milner, T. E., & Eberlin, L. S.
- Affiliations
- The University of Texas at Austin (US)
- Baylor College of Medicine (US)
- The University of Texas MD Anderson Cancer Center (US)
- Department of Chemistry, University of Texas at Austin, Austin, TX 78712, USA.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-09-06
- Volume
- 9
- Issue
- 406
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5830136
- OpenAlex
- W2753124759
- Cited by
- 406
- References
- 41
- Citations by year
- 2026: 29 · 2025: 33 · 2024: 40 · 2023: 50 · 2022: 44 · 2021: 52 · 2020: 50 · 2019: 64 · 2018: 37 · 2017: 6
- FWCI
- 21.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Cancer Institute (award310081, R00CA190783)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Keywords
- nondestructive tissue analysis, cancer diagnosis, tumor markers, molecular profiling, histopathology, thyroid tumors, breast cancer, ovarian cancer, intraoperative diagnosis, mouse tumor model
- MeSH terms
- Animals, Disease Models, Animal, Female, Humans, Intraoperative Care, Mice, Nude, Neoplasms, Organ Specificity, Mass Spectrometry, Molecular Diagnostic Techniques, Principal Component Analysis
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