The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms
Abstract
Infections refractory to conventional antibiotics may be targeted by the antimicrobial peptide SAAP-148.
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The antibacterial peptide LL-37 from humans has broad-spectrum antibacterial activity by increasing the membrane permeability of bacteria, neutralizing endotoxins, and suppressing the production of proinflammatory factors.
“The antibacterial peptide LL-37 from humans was found to have broad-spectrum antibacterial activity31–34 by increasing the membrane permeability of bacteria, neutralizing endotoxins, and suppressing the production of proinflammatory factors.35”
From Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach (2022) · cites this paper as [31]
Cites
Magiorakos, A.-P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., Harbarth, S., Hindler, J. F., Kahlmeter, G., Olsson-Liljequist, B., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03570.x · Cited by 14,449 · see citing works
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457 · see citing works
Maisetta, G., Petruzzelli, R., Brancatisano, F. L., Esin, S., Vitali, A., Campa, M., & Batoni, G. (2010) · Peptides · doi:10.1016/j.peptides.2010.08.007 · Cited by 91 · see citing works
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Zhang, X., Li, S., Luo, H., He, S., Yang, H., Li, L., Tian, T., Han, Q., Ye, J., Huang, C., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01035-6 · Cited by 14 · see citing works
- Authors
- de Breij, A., Riool, M., Cordfunke, R. A., Malanovic, N., de Boer, L., Koning, R. I., Ravensbergen, E., Franken, M., van der Heijde, T., Boekema, B. K., Kwakman, P. H. S., Kamp, N., El Ghalbzouri, A., Lohner, K., Zaat, S. A. J., Drijfhout, J. W., & Nibbering, P. H.
- Affiliations
- Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, Netherlands.
- Amsterdam UMC Location University of Amsterdam (NL)
- Leiden University Medical Center (NL)
- Biophysics Division, Institute of Molecular Biosciences, University of Graz, Naturwissenschaftliche Fakultät (NAWI) Graz, BioTechMed, 8010 Graz, Austria.
- Department of Medical Microbiology, Amsterdam Infection and Immunity Institute, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
- Leiden University (NL)
- Association of Dutch Burn Centres (NL)
- Department of Dermatology, Leiden University Medical Center, 2300 RC Leiden, Netherlands.
- University of Graz (AT)
- Corresponding author
- Riool, Martijn
- Zaat, Sebastian A. J.
- Drijfhout, Jan W.
- Nibbering, Peter H.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-01-10
- Volume
- 10
- Issue
- 423
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2783785722
- Cited by
- 555
- References
- 3
- Citations by year
- 2026: 60 · 2025: 73 · 2024: 67 · 2023: 82 · 2022: 73 · 2021: 70 · 2020: 65 · 2019: 46 · 2018: 19
- FWCI
- 40.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- FP7-Health-2011 (award310027, 278890)
- LSH-TKI (award310028, 40-43100-98-017)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- antimicrobial peptides, antibiotic resistance, biofilm, skin wound healing, ex vivo skin, mouse skin, drug candidates
- MeSH terms
- Administration, Topical, Amino Acid Sequence, Cell Membrane, Cell Membrane Permeability, Colistin, Escherichia coli, Humans, Microbial Sensitivity Tests, Ointments, Skin, Biofilms, Antimicrobial Cationic Peptides, Drug Resistance, Multiple, Bacterial, Acinetobacter baumannii, Microbial Viability, Methicillin-Resistant Staphylococcus aureus
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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