Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice
Open accessAbstract
Unlike conventional influenza vaccines, mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in infant mice.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a mouse model of H1N1 influenza, a LNP-encapsulated, nucleoside-modified mRNA encoding haemagglutinin from the Cal09 H1N1 strain partially overcame maternal antibody inhibition of de novo vaccine responses in pups.
“In a mouse model of H1N1 influenza infection in which influenza-specific maternal antibodies inhibited de novo vaccine responses in pups, a LNP-encapsulated, nucleoside-modified mRNA encoding haemagglutinin from the Cal09 H1N1 strain partially overcame this inhibition229.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [229]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 83 · Cited by 54
- Authors
- Willis, E., Pardi, N., Parkhouse, K., Mui, B. L., Tam, Y. K., Weissman, D., & Hensley, S. E.
- Affiliations
- University of Pennsylvania (US)
- Acuitas Therapeutics (Canada) (CA)
- Corresponding author
- Hensley, Scott E.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-01-08
- Volume
- 12
- Issue
- 525
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7339908
- OpenAlex
- W3000062036
- Cited by
- 54
- References
- 83
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 17 · 2023: 4 · 2022: 9 · 2021: 3 · 2020: 5
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1R01AI113047, 1R01AI108686, R01-AI050484, R01-AI124429, R01-AI084860, T32-AI070077, T32-AI055428)
- Burroughs Wellcome Fund (1015433)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- maternal antibodies, passive immunity, nucleoside-modified mRNA, mRNA-LNP vaccine, influenza vaccination, infant immunization, germinal center, vaccine immunogenicity, influenza
- MeSH terms
- Adjuvants, Immunologic, Animals, Antibodies, Viral, Antibody Formation, Disease Models, Animal, Female, Influenza Vaccines, Lipids, Mice, Inbred BALB C, Mice, Inbred C57BL, Nucleosides, Orthomyxoviridae, Orthomyxoviridae Infections, RNA, Messenger, Vaccination, Germinal Center, Hemagglutinin Glycoproteins, Influenza Virus, Mice, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
