β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade
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Noradrenergic signaling sensitizes pathological GSK3β/tau activation to nanomolar Aβ.
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β-amyloid oligomers bind to allosteric site on α2-ARs to redirect norepinephrine signaling to activate pathogenic GSK3β/tau cascade.
“A recent study has found that β-amyloid oligomers bind to an allosteric site on α2-ARs to redirect norepinephrine signaling to activate the pathogenic GSK3β/tau cascade 250.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [250]
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References 67 · Cited by 133
Research works printed but not linked: 7
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- Authors
- Zhang, F., Gannon, M., Chen, Y., Yan, S., Zhang, S., Feng, W., Tao, J., Sha, B., Liu, Z., Saito, T., Saido, T., Keene, C. D., Jiao, K., Roberson, E. D., Xu, H., & Wang, Q.
- Affiliations
- University of Alabama at Birmingham (US)
- Southern Research Institute (US)
- RIKEN Center for Brain Science (JP)
- University of Washington (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Zhang, Fang
- Gannon, Mary
- Wang, Qin
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-01-15
- Volume
- 12
- Issue
- 526
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7891768
- OpenAlex
- W2999452229
- Cited by
- 133
- References
- 67
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 18 · 2023: 14 · 2022: 28 · 2021: 20 · 2020: 23
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH081917)
- National Institute on Aging (AG056815, AG05136, AG006781)
- National Institute of Neurological Disorders and Stroke (NS062684)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid-beta, norepinephrine signaling, GSK3β, tau hyperphosphorylation, Alzheimer's disease, noradrenergic neurons, noradrenergic dysfunction
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Animals, Humans, Norepinephrine, Signal Transduction, Amyloid beta-Peptides, tau Proteins, Mice
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