APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

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Items 101–181 of 181

1. Generation of novel anti‐apo E monoclonal antibodies that selectively recognize apo E isoforms
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3. Antibody Therapies for Alzheimer’s Disease: A New Strategy for Targeted Therapy and Blood–Brain Barrier Delivery
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4. Correlation of ApoE gene polymorphism with acute myocardial infarction and aspirin resistance after percutaneous coronary intervention.
   Luoqing Wang, Chen Shao, Cuimin Han, Peng Li, Feixiang Wang, Yilian Wang, Junping Li · 2022 · PubMed
5. APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome—Implications for Clinical Trials and Treatments for All
   Cynthia Ann Lemere, Elizabeth Head, David M. Holtzman · 2021 · JAMA Neurology
6. Synergistic effects of multiple pathological processes on Alzheimer's disease risk: Evidence for age-dependent stroke interactions
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7. Mediation of Reduced Hippocampal Volume by Cerebral Amyloid Angiopathy in Pathologically Confirmed Patients with Alzheimer’s Disease
   Nandakumar Nagaraja, Wei‐en Wang, Ranjan Duara, Steven Trent DeKosky, David E. Vaillancourt · 2023 · Journal of Alzheimer s Disease
8. Molecular basis of the association between transcription regulators nuclear respiratory factor 1 and inhibitor of DNA binding protein 3 and the development of microvascular lesions
   Christian Perez, Quentin H. Felty · 2022 · Microvascular Research
9. ApoE2 affects insulin signaling in the hippocampus and spatial cognition of aged mice in a sex-dependent manner
   Yu Wang, Hanchen Liu, Yijuan Ye, Wenting Fang, Anlan Lin, Xiaoman Dai, Qinyong Ye, Xiaochun Chen, Jing Zhang · 2025 · Cell Communication and Signaling
10. Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma
    Yapeng Ji, Junyao Jiang, Lei Hu, Lin Peng, Mingshan Zhou, Song Hu, Minkai Wang, Yuchen Ji, Xianzhi Liu, Dongming Yan et al. · 2025 · Cell Research
11. APOE4 Exacerbates Alzheimer‐Like Pathologies and Cognitive Deficits Induced by Blood‐Derived Aβ in a Mouse Model
    Zhongyuan Yu, Xiaoyu Liu, Qiong‐Yan Li, Jinmei Tuo, Qi Tan, Zhihao Liu, Ziyu Yuan, Ru Zeng, Yang Zhao, Jiali Li et al. · 2025 · Aging Cell
12. Unraveling Mechanisms of Cryptogenic Stroke at the Genetic Level: A Systematic Literature Review
    Johanna Ernst, Hannelore Ehrenreich, Karin Weißenborn, Gerrit Maximilian Große · 2023 · Journal of the American Heart Association
13. Aducanumab and adenoviral COVID-19 vaccines: increased cerebral hemorrhage risk?
    ArunSundar MohanaSundaram, Shanmugarajan Thukani Sathanantham, Lukas Sveikata, Rakesh Shyam Lalla, Renata Sveikatienė, Ajeet Kumar Kaushik, V. Ravichandiran · 2022 · Expert Review of Neurotherapeutics
14. Increased tau expression in the APOE4 blood-brain barrier model is associated with reduced anti-tau therapeutic antibody delivery in vitro
    Joanna Marta Wasielewska, Rinie Bajracharya, Rebecca L. Johnston, Juliana C.S. Chaves, Alice Pébay, Lotta E. Oikari, Jürgen Götz, Rebecca M. Nisbet, Anthony Robert White · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
15. Spontaneous mammalian models for Alzheimer's disease and dementia
    Madeleine Ford, Frank J. Gunn‐Moore, Mark Patrick Dagleish · 2025 · Brain Communications
16. APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodegeneration (N), halting progressive ATN pathology in a preclinical model
    Sarah Vanherle, Art Janssen, Manuel Gutiérrez de Ravé, Bieke Janssen, Chritica Lodder, Pablo Botella Lucena, Sofie Kessels, Jana Hardy, Eline Vandeput, Yanyan Wang et al. · 2025 · Molecular Psychiatry
17. Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer’s disease mouse model
    Jessica R. Blumenfeld, Yaqiao Li, Min Joo Kim, Oscar Yip, Leon Yao, Samuel De Leon, Rebecca Fulthorpe, David M. Shostak, Zoe Platow, Kaylie Suan et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
18. Intervention Role of APOE in CNS Diseases: APOE Actions and APOE Neurogenesis Capability
    Wenhua Li, Suya Ma, Min Li · 2025 · Molecular Neurobiology
19. Molecular carriers enable precision delivery and region-specific neuroprotection by dietary DHA in the mouse brain
    Xiaochun Chen, Wei Sun, Hongliang Zhang, Yanjiao Li, Ruikun He, Zhengjiang Qian · 2026 · Nutritional Neuroscience
20. A quantitative trait locus for reduced microglial APOE expression associates with reduced cerebral amyloid angiopathy
    Michaël E. Belloy, Jonathan Graff‐Radford, Michael D. Greicius · 2026 · Nature Genetics
21. One Hundred Cerebral Microhemorrhages: Rethinking Cerebral Amyloid Angiopathy in the Era of Amyloid-Targeted Antibodies
    A Navarra, Jeffrey R. Petrella, Andy J Liu, Salman S. Ikramuddin, Pudugramam Murali Doraiswamy · 2026 · Cureus
22. Longitudinal multiphoton imaging of cerebral amyloid angiopathy in response to anti-ApoE4 immunotherapy in mice
    Orla Bonnar, Fareeha Saadi, Maria Virtudes Sanchez-Mico, Lee H. Hanlin, Kali A. vom Eigen, Nicole Mumbi, Brian J. Bacskai, Steven Mark Greenberg, David M. Holtzman, Susanne J. van Veluw · 2026 · Molecular Neurodegeneration
23. Advances in the treatment of Alzheimer’s disease
    Rezzan Temelli Goceroglu, Ahmet Hacımüftüoğlu · 2026 · Frontiers in Pharmacology
24. Comparative risk of amyloid-related imaging abnormalities with anti–amyloid-β monoclonal antibodies: A systematic review and penalized likelihood network meta-analysis of randomized trials
    Arkansh Sharma, Vinay Suresh, Pavan Raju Kola, R. Ajith Raj, FNU Javairia, Allimuthu Nithyanandam, Anmol Kaur, Himanshu Arora, Olivier Uwishema, Dhanya Gorty et al. · 2026 · Journal of Alzheimer s Disease
25. Antibody targets apolipoprotein E to remove amyloid-β deposits
    Sarah A. Lemprière · 2021 · Nature Reviews Neurology
26. 阿尔茨海默症治疗的药物突破
    Qiang Liu · 2024 · Chinese Science Bulletin (Chinese Version)
27. The Inner Link between Apolipoprotein E and the risk of Alzheimer’s disease
    Boyuan Zheng · 2024 · MedScien
28. Callistephin inhibits amyloid-β protein aggregation and determined cytotoxicity against cerebrovascular smooth muscle cells as an in vitro model of cerebral amyloid angiopathy
    E. Ruifang, Yaling Shi, Weiwei Wang, Ming Qi · 2021 · Arabian Journal of Chemistry
29. APOE ε4 and exercise interact to influence systemic and cerebral risk factors for dementia
    Kate E. Foley, Cory A. Diemler, Amanda A. Hewes, Dylan T. Garceau, Michael Sasner, Gareth R. Howell · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
30. A Quantitative Trait Locus for Reduced Microglial APOE Expression Associates with Reduced Cerebral Amyloid Angiopathy
    Michaël E. Belloy, Jonathan Graff‐Radford, Michael D. Greicius · 2025 · medRxiv
31. AAV-based temporal APOE4-to-APOE2 replacement reveals rebound adaptation and RAB24-mediated Aβ and cholesterol dysregulation
    Ruihan Yang, Yue Li, Xingchen Zhao, Lin Wang, Jialin Wu, Jian Sima · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
32. An in vivo model of Amyloid-Related Imaging Abnormalities (ARIA) predicts ARIA incidence of anti-Aβ antibodies seen in clinical trials
    Edward D. Plowey, Jordan Abettan, Peter Cheng‐te Chou, Ming Lye‐Barthel, Ana Claudia Silva Amaral, Jennifer Sebalusky, Stefan Hamann, Jared Srinivasan, Roland Z. Brown, Qian Fang et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
33. Imunoterapia no tratamento das doenças neurodegenerativas
    Luiza Nacur Pinheiro, Pedro Vieira Silva, Lara Narciso Guedes, Rafael Salomão de Alvarenga Alves, Beatriz Aguiar Oliveira Netto · 2024 · Brazilian Journal of Health Review
34. Functional Proteins/Peptides Targeting to Clear Amyloid‐β for Alzheimer's Disease Therapy
    Ziran Gao, Renjie Hou, Chenggen Qian · 2025 · ChemBioChem
35. A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy
    Zixu Liu, Yuchen Mao, Shukai Wang, Haoyu Zheng, Kangping Yang, Liang Yang, Peng Huang · 2025 · Frontiers in Immunology
36. Anti-Aβ immunotherapy-mediated amyloid clearance attenuates microglial activation without inducing exhaustion at residual plaques
    Lis de Weerd, Selina Hummel, Stephan A. Müller, Iñaki Paris, Thomas Sandmann, Marie Eichholtz, Robin Gröger, Amelie L. Englert, Stephan Wagner, Connie Ha et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
37. Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer’s disease
    Seiichiro Sakai, Kento Otani, Jun Tsuyama, Yuichiro Hara, K. Abe, Teppei Shimamura, Ito Kawakami, Takashi Komori, Hideya Kawaji, Koji Hase et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
38. β-Amyloid as a new target to suppress tonic PTH hypersecretion in primary hyperparathyroidism
    Chia‐Ling Tu, Zhiqiang Cheng, Nicholas Szeto, Sofya Savransky, Timofey S. Glinin, Dolores Shoback, Julie Ann Sosa, Jean‐Pierre Vilardaga, James Koh, Wenhan Chang · 2025 · medRxiv
39. Genetic Polymorphisms of Apolipoprotein E and Their Impact on Ischemic Stroke Severity and Recovery
    Hang Yuan, Ping Li, Bin Li · 2025 · Neurology and Clinical Neuroscience
40. Modular inflammation network discovery from large-scale phenotypic screening in genetically heterogeneous mouse brains
    Monica Xiong, Lisa A. Miosge, Carolina Correa-Ospina, Claudia M. Y. Yan, Tiffany Cripps, Stefan Bauernfried, Yuanyuan Wang, Maggie Crow, Lucy X. Morris, T. Daniel Andrews et al. · 2025 · Journal of Neuroinflammation
41. PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation
    Mengqi Zhang, Anudari Letian, Gregory A. Mohl, Brynn Kroke, Kajsa Arkelius, Claire Dudley Clelland, Emily L. Goldberg, Neel S. Singhal · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
42. Precision medicine in neurodegenerative diseases: From research to clinical practice
    Baskaran Gunasekaran, Amar Harris Arifin, Wong Hong Yu, Saema Hanafi, Kirtana Devi Kumara Rao, Shamala Salvamani · 2025 · Progress in brain research
43. Migraine and Dementia: A Narrative Review of Current Evidence
    Arbind Kumar Choudhary · 2025 · Psikhiatriya
44. Additional file 1 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
45. Additional file 2 of Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains
    Tarin M. Bigley, Monica Xiong, Muhammad Ali, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Abdallah M. Eteleeb, Oscar Harari, Liping Yang, Swapneel J. Patel et al. · 2022 · Figshare
46. Additional file 3 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
47. Additional file 5 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
48. Additional file 4 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
49. Additional file 4 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
50. Additional file 2 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
51. Additional file 6 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
52. Additional file 3 of Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains
    Tarin M. Bigley, Monica Xiong, Muhammad Ali, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Abdallah M. Eteleeb, Oscar Harari, Liping Yang, Swapneel J. Patel et al. · 2022 · Figshare
53. Additional file 2 of Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease
    Ito, Shingo, Ryotaro Yagi, Seiryo Ogata, Masuda, Takeshi, Saito, Takashi, Saido, Takaomi, Sumio Ohtsuki · 2024 · Figshare
54. Additional file 3 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
55. Additional file 1 of Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease
    Ito, Shingo, Ryotaro Yagi, Seiryo Ogata, Masuda, Takeshi, Saito, Takashi, Saido, Takaomi, Sumio Ohtsuki · 2024 · Figshare
56. Additional file 10 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
57. Additional file 8 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
58. Additional file 1 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
59. Additional file 1 of Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains
    Tarin M. Bigley, Monica Xiong, Muhammad Ali, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Abdallah M. Eteleeb, Oscar Harari, Liping Yang, Swapneel J. Patel et al. · 2022 · Figshare
60. Additional file 6 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Wang, Chao, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
61. Additional file 2 of Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Bao, Xin, Megan E. Bosch, Choonghee Lee, Hong Jiang, Serrano, Javier Remolina, Ernesto R. Gonzales et al. · 2023 · Figshare
62. Additional file 9 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
63. Additional file 11 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
64. Additional file 5 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
65. Additional file 7 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
    Xavier Taylor, Isaiah Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald Bradley Demattos, Yaming Wang, Pan, Feng · 2024 · Figshare
66. APOE Gene Editing as a Therapeutic Target Toward Precision Medicine in AD
    Bruce Teter, Jesus J. Campagna, Patricia R. Spilman, Varghese John · 2025 · Springer eBooks
67. The causal relationship between multiple cardiovascular diseases and glioblastoma: A Mendelian randomization study
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68. Amyloid-β as a target to suppress tonic PTH hypersecretion in hyperparathyroidism due to vitamin D deficiency
    Chia‐Ling Tu, Zhiqiang Cheng, Nicholas Szeto, Sofya Savransky, Timofey S. Glinin, Amanda L. Herberger, Dolores Shoback, Julie Ann Sosa, Jean‐Pierre Vilardaga, James Koh et al. · 2026 · Science Translational Medicine
69. Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’Alzheimer
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70. Diversité clinico-radiologique des microangiopathies cérébrales : Etude phénotypique et génétique de l’angiopathie amyloïde cérébrale et des calcifications cérébrales primaires
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71. The concurrent burden of Alzheimer’s pathology, cerebral amyloid angiopathy, and microinfarcts on cognitive decline
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72. APOE Gene Editing as a Therapeutic Target Toward Precision Medicine in AD
    Bruce Teter, Jesus J. Campagna, Patricia Spilman, Varghese John · 2026 · Springer eBooks
73. Ex vivo comparison of ACU193 and lecanemab reveals binding differences in mouse brain
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75. Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition
    Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato · 2026 · MedComm
76. The diagnostic and therapeutic significance of apolipoprotein E in personalized medicine
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77. Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice
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78. A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration
    Braxton Riley Schuldt, Dominic Haworth-Staines, Andrea Pérez Arévalo, Diede W. M. Broekaart, Ashley Harlock, Leon Wang, Anna Bright, Georgia Gallagher, Grace Rabinowitz, Alison Goate et al. · 2026 · Cell
79. Microglial Therapeutic Potential in Alzheimer’s Disease: From Phenotypic Diversity to Targeted Interventions
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80. Supplementary data & code for "Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques"
    Thomas Sandmann · 2025 · Zenodo (CERN European Organization for Nuclear Research)
81. Modern Concepts of Amyloidosis Pathogenesis: Effective Diagnosis, Therapy, and Prognosis
    M. M. Shavlovsky, Антимонова Ольга Игоревна, Н. А. Грудинина, D. S. Polyakov, Vladimir V. Egorov, K. V. Masterova, M. A. Karaeva, D. E. Korzhevskii, V. V. Guselnikova, O. V. Shamova et al. · 2026 · Cell and Tissue Biology