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Cited by 336Transplantation: Methods and OutcomesCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Lung transplantation for patients with severe COVID-19

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Bharat, Ankit, Querrey, Melissa, Markov, Nikolay S., Kim, Samuel, Kurihara, Chitaru, Garza-Castillon, Rafael, Manerikar, Adwaiy, Shilatifard, Ali +7 more·2020·Science Translational Medicine
DOI 10.1126/scitranslmed.abe4282PMC PMC8050952

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Abstract

Some patients with severe COVID-19 develop end-stage pulmonary fibrosis for which lung transplantation may be the only treatment.

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Crossref · 10.1126/scitranslmed.abe4282

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  • In patients with ARDS without underlying lung disease, transplantation may be indicated if the patient is not withdrawn from the ventilator or if there is evidence of irreversible lung injury.

    “In patients with acute respiratory distress syndrome (ARDS) without underlying lung disease, transplantation may be indicated if the patient is not withdrawn from the ventilator or if there is evidence of irreversible lung injury.”

    From Indications for Lung Transplantation and Patient Selection (2022) · cites this paper as [66]

    The Discussion (page unavailable) supports considering transplantation for irreversible lung disease after severe COVID-19, generally only after 4–6 weeks of mechanical ventilation to allow for possible recovery. It does not extend that recommendation to ARDS generally or say that inability to come off a ventilator alone is an indication. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Transplantation has recently become an important option in cases of irreversible fibrotic changes of the lungs in ARDS caused by COVID-19.

    “Transplantation has recently become an important option in cases of irreversible fibrotic changes of the lungs in ARDS caused by coronavirus disease 2019 [66,67].”

    From Indications for Lung Transplantation and Patient Selection (2022) · cites this paper as [66]

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References 44 · Cited by 336

Research works printed but not linked: 28

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Authors
Bharat, A., Querrey, M., Markov, N. S., Kim, S., Kurihara, C., Garza-Castillon, R., Manerikar, A., Shilatifard, A., Tomic, R., Politanska, Y., Abdala-Valencia, H., Yeldandi, A. V., Lomasney, J. W., Misharin, A. V., & Budinger, G. R. S.
Affiliations
  • Northwestern University (US)
  • Division of Thoracic Surgery, Northwestern Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  • Division of Pulmonary and Critical Care Medicine, Northwestern Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Corresponding author
Bharat, Ankit
ORCID
Venue
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Published
2020-12-16
Volume
12
Issue
574
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
DOI
10.1126/scitranslmed.abe4282
PMC
PMC8050952
OpenAlex
W3110514822
Cited by
336
References
44
Citations by year
2026: 15 · 2025: 29 · 2024: 37 · 2023: 74 · 2022: 99 · 2021: 79 · 2020: 3
FWCI
58.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Science Translational Medicine (publishedVersion, cc-by)
  • medRxiv (acceptedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (submittedVersion)
Funders
  • National Institute on Aging (AG049665)
  • National Heart, Lung, and Blood Institute (HL147290, HL145478, HL147575, HL153312)
  • National Institute of Allergy and Infectious Diseases (AI135964)
  • U.S. Department of Veterans Affairs (I01CX001777)
  • Northwestern University (NUCATS COVID-19 Rapid Response Grant)
  • Chan Zuckerberg Initiative (CZI Seed Networks for the Human Cell Atlas)
Topics
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
lung transplantation, COVID-19 pandemic, SARS-CoV-2, pulmonary fibrosis, ventilator-associated pneumonia, single-cell RNA sequencing, single-molecule fluorescence in situ hybridization, machine learning, gene expression comparison, end-stage lung disease

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