Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19.
Open accessAbstract
Hospitalized patients with COVID-19 show increased serum concentrations of neurofilament light chain that correlate with worse clinical outcomes.
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Inflammatory markers remain abnormal for months after recovery, particularly in severe COVID-19 cases.
“inflammatory factors have been shown to not return to normal status months after recovery, especially in individuals with severe COVID-19”
From One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China: A Longitudinal Cohort Study (2022) · cites this paper as [34]
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References 36 · Cited by 78
Research works printed but not linked: 1
- [37]37. A. Pilotto, V. Cristillo, S. C. Piccinelli, N. Zoppi, G. Bonzi, D. Sattin, S. Schiavolin, A. Raggi, A. Canale, S. Gipponi, I. Libri, M. Frigerio, M. Bezzi, M. Leonardi, A. Padovani, COVID-19 severity impacts on long-term neurological manifestation after hospitalisation. medRxiv 2020.12.27.20248903 (2021).
- Authors
- Prudencio, M., Erben, Y., Marquez, C. P., Jansen-West, K. R., Franco-Mesa, C., Heckman, M. G., White, L. J., Dunmore, J. A., Cook, C. N., Lilley, M. T., Song, Y., Harlow, C. F., Oskarsson, B., Nicholson, K. A., Wszolek, Z. K., Hickson, L. J., O’Horo, J. C., Hoyne, J. B., Gendron, T. F., Meschia, J. F., & Petrucelli, L.
- Affiliations
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
- Massachusetts General Hospital (US)
- Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
- Corresponding author
- Prudencio, Mercedes
- Erben, Young
- Meschia, James F.
- Petrucelli, Leonard
- ORCID
- Prudencio, Mercedes
- Erben, Young
- Marquez, Christopher P.
- Jansen-West, Karen R.
- Franco-Mesa, Camila
- Heckman, Michael G.
- White, Launia J.
- Dunmore, Judith A.
- Cook, Casey N.
- Lilley, Meredith T.
- Song, Yuping
- Harlow, Caroline F.
- Oskarsson, Björn
- Wszolek, Zbigniew K.
- Hickson, LaTonya J.
- O’Horo, John C.
- Hoyne, Jonathan B.
- Gendron, Tania F.
- Meschia, James F.
- Petrucelli, Leonard
- Venue
- Science Translational Medicine
- Published
- 2021-07-14
- Volume
- 13
- Issue
- 602
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8432951
- OpenAlex
- W3172731736
- Cited by
- 78
- References
- 36
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 24 · 2022: 31 · 2021: 5
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science Translational Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R35 NS097273, P01 NS084974, P01 NS099114, U01 NS080168, U19 NS115388, RF1 NS120992)
- The Donald G and Jodi P Heeringa Family
- The Earl & Nyda Swanson Neurosciences Research Fund
- The Harley N and Rebecca N Hotchkiss Endowed Fund in Neuroscience Research, Honoring Ken and Marietta
- Mayo Clinic Center for Regenerative Medicine
- Mayo Clinic in Florida Focused Research Team Program
- Gifts from The Sol Goldman Charitable Trust, the Haworth Family Professorship in Neurodegenerative Diseases fund, and The Albertson Parkinson’s Research Foundation
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- COVID-19 pandemic, neurofilament light chain, neuroaxonal damage, neurological sequelae, remdesivir, hospitalized patients, clinical outcome prediction, neuroinflammation biomarkers, long COVID
- MeSH terms
- COVID-19, SARS-CoV-2, Humans, Intermediate Filaments, Magnetic Resonance Imaging, Prospective Studies, Biomarkers, Neurofilament Proteins, Tumor Necrosis Factor Ligand Superfamily Member 14
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