Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior
Open accessAbstract
cAMP-mediated effect on HCN channel surface trafficking and mouse behavior depends on activation time scale.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic stress elevates HCN1 and Ih in dorsal CA1, reducing excitability and producing depressive behaviors.
“chronic stress elevates HCN1 and Ih in dorsal Cornu Ammonis area 1 (CA1), reducing excitability and producing depressive behaviors”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [292]
The Introduction (page unavailable) reports greater dorsal-hippocampal HCN-channel expression in a rodent model of chronic stress. It also links dorsal CA1 HCN-channel knockdown to antidepressant-like behavior, but our copy does not establish the claimed chain that stress raises HCN1 and Ih in dorsal CA1, thereby reducing excitability and producing depressive behaviors. (LLM, conf=0.84)
Experimental — accuracy not yet measuredLowering HCN surface expression via cAMP signaling or direct HCN1 inhibition rescues stress-related cognitive deficits and post-stroke affective slowing.
“lowering HCN surface expression via cAMP signaling or direct HCN1 inhibition rescues stress-related cognitive deficits and post-stroke affective slowing [289,292,293]”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [292]
The Abstract and Results ('Hippocampal cAMP signaling rescues spatial memory deficits after chronic social defeat'; page unavailable) report that chronically elevated hippocampal cAMP reduced HCN surface trafficking and rescued spatial memory and motivated behavior after chronic stress in mice. They do not report a rescue of post-stroke affective slowing or demonstrate rescue through direct HCN1 inhibition. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 96 · Cited by 17
- Authors
- Lyman, K. A., Han, Y., Zhou, C., Renteria, I., Besing, G.-L., Kurz, J. E., & Chetkovich, D. M.
- Affiliations
- Northwestern University (US)
- Vanderbilt University Medical Center (US)
- Corresponding author
- Lyman, Kyle A.
- Han, Ye
- Zhou, Chengwen
- Chetkovich, Dane M.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2021-11-24
- Volume
- 13
- Issue
- 621
- Pages
- eabl4580-eabl4580
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC9196047
- OpenAlex
- W3215215767
- Cited by
- 17
- References
- 96
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 3
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH106511, R21MH126272, R21MH104471, R21MH113262)
- National Eye Institute (P30EY008126)
- National Cancer Institute (P30CA068485)
- National Institute of Diabetes and Digestive and Kidney Diseases (U24DK059637, P30DK058404, P30DK020593)
- National Institute of Neurological Disorders and Stroke (R21NS096483, R01NS107424, R21NS052595, R01NS059934)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD103537)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- HCN channels, cAMP signaling, hippocampus, TRIP8b, spatial memory, motivated behavior, chronic stress, major depressive disorder, cognitive impairment, chemogenetics, neuronal excitability
- MeSH terms
- Animals, Behavior, Animal, Major Depressive Disorder, Hippocampus, Mice, Cyclic Nucleotide-Gated Cation Channels, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
