A progress report on translational control in eukaryotes
Abstract
An extraordinary amount of regulation goes into making sure that protein expression is controlled correctly. Several layers of regulation function to achieve the proper levels and proper timing of protein expression. Much is known about the protein machinery involved in translation, but we are lagging behind in understanding the mechanisms of control in eukaryotes. Kozak reviews the new second edition of Translational Control of Gene Expression , which attempts to catalog the mechanisms used by prokaryotes and eukaryotes, and the viruses that infect them and subvert their translational machinery. Review and commentary on Translational Control of Gene Expression Edited by Nahum Sonenberg, John W. B. Hershey, and Michael B. Mathews Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 2000, 1020 pp. $115 ISBN: 0-87969-568-4
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is little evidence that +4G and downstream nucleotides contribute to translation initiation.
“There is little evidence that +4G and downstream nucleotides contribute to translation initiation.”
From Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines (2021) · cites this paper as [49]
The effect of +4G and downstream nucleotides on translation initiation has been inconclusive.
“First, while the -3R (site 4 in the first column of Table 5) has been demonstrated repeatedly to enhance translation initiation, the effect of +4G (site 10 in Table 5), as well as nucleotides downstream, on translation initiation has been inconclusive [46,49,50,51].”
From Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines (2021) · cites this paper as [49]
The -3R has been demonstrated repeatedly to enhance translation initiation.
“First, while the -3R (site 4 in the first column of Table 5) has been demonstrated repeatedly to enhance translation initiation, the effect of +4G (site 10 in Table 5), as well as nucleotides downstream, on translation initiation has been inconclusive [46,49,50,51].”
From Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines (2021) · cites this paper as [49]
Cited by
Sorted by citations
Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines
Xia, X. (2021) · Vaccines · doi:10.3390/vaccines9070734 · Cited by 201 · see citing works
- Authors
- Kozak, M.
- Affiliations
- University of Medicine and Dentistry of New Jersey (US)
- Corresponding author
- Kozak, Marilyn
- Venue
- Science's STKE
- Published
- 2001-02-27
- Volume
- 2001
- Issue
- 71
- Pages
- pe1-pe1
- ISSN
- 1937-9145 (ISSN-L)
- 1525-8882
- OpenAlex
- W1977196999
- Cited by
- 12
- References
- 0
- Citations by year
- 2022: 1 · 2021: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Signaling (publishedVersion)
- Science s STKE (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- translational regulation, eukaryotic translation, gene expression regulation, prokaryotic translation, translation machinery
- MeSH terms
- Animals, Eukaryotic Cells, Gene Expression Regulation, Humans, Protein Biosynthesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
