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Cited by 50Malaria Research and ControlAntibiotics Pharmacokinetics and EfficacyPharmacogenetics and Drug Metabolism

Pharmacokinetics of Amodiaquine and Desethylamodiaquine in Pregnant and Postpartum Women with Plasmodium vivax Malaria

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Rijken, Marcus J., McGready, Rose, Jullien, Vincent, Tarning, Joel, Lindegardh, Niklas, Phyo, Aung Pyae, Win, Aye Kyi, Hsi, Poe +4 more·2011·Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.00154-11PMC PMC3165320
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Abstract

In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and with Plasmodium vivax malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days. The same women were studied again at 3 months postpartum. Plasma was analyzed for amodiaquine and desethylamodiaquine by use of a liquid chromatography-tandem mass spectrometry method. Individual concentration-time data were evaluated using noncompartmental analysis. There were no clinically relevant differences in the pharmacokinetics of amodiaquine and desethylamodiaquine between pregnant (n = 24) and postpartum (n = 18) women. The results suggest that the current amodiaquine dosing regimen is adequate for the treatment of P. vivax infections during pregnancy.

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Crossref · 10.1128/aac.00154-11

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  • A pharmacokinetics study on AQ for treatment of P. vivax in pregnancy conducted in Thailand indicates the doses are similar to that of non-pregnant adults.

    “A pharmacokinetics study on AQ for treatment of P.vivax in pregnancy conducted in Thailand indicates the doses are similar to that of non-pregnant adults.131,135”

    From Malaria in pregnancy. (2013) · cites this paper as [131]

  • Data available indicate that ACTs are relatively safe for the foetus when taken after the first trimester of pregnancy.

    “Data available indicate that ACTs are relatively safe for the foetus when taken after the first trimester of pregnancy.”

    From Malaria in pregnancy. (2013) · cites this paper as [131]

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Authors
Rijken, M. J., McGready, R., Jullien, V., Tarning, J., Lindegardh, N., Phyo, A. P., Win, A. K., Hsi, P., Cammas, M., Singhasivanon, P., White, N. J., & Nosten, F.
Affiliations
  • Shoklo Malaria Research Unit (TH)
  • Mahidol University (TH)
  • Inserm (FR)
  • Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Corresponding author
Nosten, François
ORCID
Venue
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Published
2011-09
Volume
55
Issue
9
Pages
4338-4342
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
DOI
10.1128/aac.00154-11
PMC
PMC3165320
OpenAlex
W2057464338
Cited by
50
References
2
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 5
FWCI
4.40
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust (093956, 093956/Z/10/Z)
  • University of Oxford
  • Mahidol University
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
amodiaquine, desethylamodiaquine, pharmacokinetics, vivax malaria, pregnancy, postpartum women, plasma drug concentration
MeSH terms
Adolescent, Adult, Amodiaquine, Antimalarials, Female, Humans, Pregnancy, Malaria, Vivax, Postpartum Period, Young Adult

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