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Cited by 14Antimicrobial Peptides and ActivitiesAntifungal resistance and susceptibilityAntimicrobial agents and applications

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The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans

Open access
Lin, Guan-Yu, Chen, Hsueh-Fen, Xue, Yao-Peng, Yeh, Ying-Chieh, Chen, Chia-Lu, Liu, Ming-Sun, Cheng, Wen-Chi, Lan, Chung-Yu·2016·Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.00699-16PMC PMC5038333
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Abstract

Two antimicrobial P-113 peptide derivatives, P-113Du and P-113Tri, were investigated in this study. Notably, P-113Du and P-113Tri contained significant fractions of α-helix conformation and were less sensitive to high salt and low pH than P-113. Moreover, compared to P-113, these peptides exhibited increased antifungal activity against planktonic cells, biofilm cells, and clinical isolates of Candida albicans and non- albicans Candida spp. These results suggest that P-113Du and P-113Tri are promising candidates for development as novel antifungal agents.

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Metadata

Authors
Lin, G.-Y., Chen, H.-F., Xue, Y.-P., Yeh, Y.-C., Chen, C.-L., Liu, M.-S., Cheng, W.-C., & Lan, C.-Y.
Affiliations
  • National Tsing Hua University (TW)
  • General Biologicals Corporation, Hsinchu, Taiwan
ORCID
Venue
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Published
2016-10
Volume
60
Issue
10
Pages
6369-6373
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
DOI
10.1128/aac.00699-16
PMC
PMC5038333
OpenAlex
W2499863882
Cited by
14
References
1
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1
FWCI
1.37
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • General Biologicals Corporation
  • Ministry of Science and Technology, Taiwan (MOST104-2622-B-007-001-CC2)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Keywords
antimicrobial peptides, Candida albicans, antifungal activity, Candida biofilms, non-albicans Candida, alpha-helix conformation, peptide stability, antifungal agents
MeSH terms
Antifungal Agents, Ascorbic Acid, Candida albicans, Drug Evaluation, Preclinical, Humans, Hydrogen-Ion Concentration, Microbial Sensitivity Tests, Plankton, Protein Conformation, Biofilms, Histatins

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