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Cited by 286

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World

Open access
Drawz, Sarah M., Papp-Wallace, Krisztina M., Bonomo, Robert A.·2014·Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.00826-13
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Abstract

As the incidence of Gram-negative bacterial infections for which few effective treatments remain increases, so does the contribution of drug-hydrolyzing β-lactamase enzymes to this serious clinical problem. This review highlights recent advances in β-lactamase inhibitors and focuses on agents with novel mechanisms of action against a wide range of enzymes. To this end, we review the β-lactamase inhibitors currently in clinical trials, select agents still in preclinical development, and older therapeutic approaches that are being revisited. Particular emphasis is placed on the activity of compounds at the forefront of the developmental pipeline, including the diazabicyclooctane inhibitors (avibactam and MK-7655) and the boronate RPX7009. With its novel reversible mechanism, avibactam stands to be the first new β-lactamase inhibitor brought into clinical use in the past 2 decades. Our discussion includes the importance of selecting the appropriate partner β-lactam and dosing regimens for these promising agents. This “renaissance” of β-lactamase inhibitors offers new hope in a world plagued by multidrug-resistant (MDR) Gram-negative bacteria.

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Registry

Crossref · 10.1128/aac.00826-13

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Metadata

Authors
Drawz, S. M., Papp-Wallace, K. M., & Bonomo, R. A.
Venue
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Published
2014-04
Volume
58
Issue
4
Pages
1835-1846
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
DOI
10.1128/aac.00826-13
OpenAlex
W2139911027
Cited by
286
References
99
FWCI
12.17
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World. https://app.cochat.ai/papers/10.1128/aac.00826-13
The paper
Drawz, S. M., Papp-Wallace, K. M., & Bonomo, R. A. (2014). New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00826-13

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.