Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens
Open accessAbstract
The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii , Pseudomonas aeruginosa , Staphylococcus aureus , Klebsiella pneumoniae , and Escherichia coli . Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus . Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.
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Iron chelators have potential as alternative treatment for multiple drug-resistant infections.
“They also have potential as alternative treatment for multiple drug-resistant infections (Thompson et al., 2012).”
From Iron at the Centre of Candida albicans Interactions (2018) · cites this paper as Thompson et al., 2012
Despite decades of work, three approved drugs for iron overload, and in vitro microbistatic evidence for some compounds, no chelator is yet used as an antimicrobial therapy.
“Despite several decades of research in this area that have yielded three successful drugs for the treatment of iron overload disorders, and evidence of in vitro microbistatic activity for several compounds95, no chelator has yet been adopted as an antimicrobial therapeutic.”
From Iron homeostasis in host defence and inflammation (2015) · cites this paper as [95]
The hydroxamate desferal and the hydroxypyridinone deferiprone are accessible by various microorganisms, restricting their potential use as microbial control agents.
“However, the hydroxamate desferal and the hydroxypyridinone deferiprone have been shown to be accessible by various micoorganisms thereby restricting their potential use as microbial control agents [50].”
From The utility of iron chelators in the management of inflammatory disorders (2015) · cites this paper as [50]
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Cites
Zarember, K. A., Cruz, A. R., Huang, C.-Y., & Gallin, J. I. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01547-08 · Cited by 78 · see citing works
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Research works printed but not linked: 1
- Reyes HM, Tingle EJ, Fenves AZ, Spiegel J, Burton EC. 2008. Pulmonary invasive mucormycosis in a patient with secondary iron overload following deferoxamine therapy. Proc. (Bayl. Univ. Med. Cent.). 21:378 -381.
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Iron homeostasis in host defence and inflammation
Ganz, T., & Nemeth, E. (2015) · Nature Reviews Immunology · doi:10.1038/nri3863 · Cited by 843 · see citing works
Antimicrobial Activity of Gallium Compounds on ESKAPE Pathogens
Hijazi, S., Visaggio, D., Pirolo, M., Frangipani, E., Bernstein, L., & Visca, P. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00316 · Cited by 144 · see citing works
Iron at the Centre of Candida albicans Interactions
Fourie, R., Kuloyo, O. O., Mochochoko, B. M., Albertyn, J., & Pohl, C. H. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00185 · Cited by 118 · see citing works
The utility of iron chelators in the management of inflammatory disorders
Lehmann, C., Islam, S., Jarosch, S., Zhou, J., Hoskin, D., Greenshields, A., Al-Banna, N., Sharawy, N., Sczcesniak, A., Kelly, M., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/516740 · Cited by 54 · see citing works
“However, the hydroxamate desferal and the hydroxypyridinone deferiprone have been shown to be accessible by various micoorganisms thereby restricting their potential use as microbial control agents [50].”
BackgroundSavage, K. A., Parquet, M. D. C., Allan, D. S., Davidson, R. J., Holbein, B. E., Lilly, E. A., & Fidel, P. L. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02576-17 · Cited by 53 · see citing works
- Authors
- Thompson, M. G., Corey, B. W., Si, Y., Craft, D. W., & Zurawski, D. V.
- Affiliations
- Walter Reed Army Institute of Research (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2012-10
- Volume
- 56
- Issue
- 10
- Pages
- 5419-5421
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC3457357
- OpenAlex
- W1998788539
- Cited by
- 135
- References
- 1
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 13 · 2023: 11 · 2022: 6 · 2021: 15 · 2020: 15 · 2019: 10 · 2018: 16 · 2017: 9 · 2016: 12 · 2015: 10 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- Walter Reed Army Institute of Research
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- iron chelators, antibacterial activity, nosocomial pathogens, deferoxamine, deferiprone, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, bacteriostatic activity, time-kill kinetics
- MeSH terms
- Deferiprone, Anti-Bacterial Agents, Deferoxamine, Iron Chelating Agents, Klebsiella pneumoniae, Microbial Sensitivity Tests, Pseudomonas aeruginosa, Pyridones, Staphylococcus aureus, Acinetobacter baumannii
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