Point Mutation or Overexpression of Aspergillus fumigatus cyp51B, Encoding Lanosterol 14α-Sterol Demethylase, Leads to Triazole Resistance
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Aspergillus fumigatus is the most common cause of invasive fungal mold infections in immunocompromised individuals. Current antifungal treatment relies heavily on the triazole antifungals which inhibit fungal Erg11/Cyp51 activity and subsequent ergosterol biosynthesis.
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Introduction of a G457S Cyp51B substitution into a susceptible recipient conferred voriconazole resistance.
“Recently, it was demonstrated that introduction of a G457S Cyp51B substitution, originally identified in a resistant clinical isolate, into a susceptible recipient conferred voriconazole resistance, reinforcing the notion that mutations in cyp51B should be monitored in the context of clinical resistance17.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [17]
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References 18 · Cited by 30
- Authors
- Handelman, M., Meir, Z., Scott, J., Shadkchan, Y., Liu, W., Ben-Ami, R., Amich, J., & Osherov, N.
- Affiliations
- Tel Aviv University (IL)
- Manchester Academic Health Science Centre (GB)
- Peking University First Hospital (CN)
- Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
- Corresponding author
- Osherov, Nir
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2021-09-17
- Volume
- 65
- Issue
- 10
- Pages
- e0125221-e0125221
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC8448118
- OpenAlex
- W3203399528
- Cited by
- 30
- References
- 18
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation (2444/18)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Aspergillus fumigatus, CYP51B, triazole resistance, ergosterol biosynthesis, ERG11, point mutations, overexpression, antifungal resistance, invasive fungal infections
- MeSH terms
- Antifungal Agents, Aspergillus fumigatus, Cytochrome P-450 Enzyme System, Fungal Proteins, Humans, Lanosterol, Mutation, Sterols, Triazoles, Point Mutation, Drug Resistance, Fungal
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