Rapid emergence of echinocandin resistance during Candida kefyr fungemia treatment with caspofungin
Open accessAbstract
Echinocandin drugs are widely used for the treatment of candidemia. Resistance is considered rare, and only a few cases of breakthrough candidiasis in patients receiving echinocandin have been reported worldwide. We report here for the first time a Candida kefyr isolate that acquired echinocandin resistance very rapidly after the initiation of caspofungin treatment for candidemia. We characterized the FKS gene mutation responsible for the resistance via the comparison of isolates sampled before and during treatment.
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Multidrug resistance is not restricted to C. glabrata or C. auris; other examples include C. kefyr, C. lusitaniae, and C. albicans.
“However, MDR is not restricted to C. glabrata or C. auris. Other examples include C. kefyr [57], C. lusitaniae [58], and C. albicans [59,60,61].”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [57]
Most reports of acquired echinocandin resistance are case reports or case series, which collectively document the potential of resistance development in almost all species that are not intrinsically susceptible.
“Most are case reports or case series, which collectively document the potential of resistance development in almost all species that are not intrinsically susceptible (9–15).”
From Echinocandin resistance: an emerging clinical problem? (2014) · cites this paper as [13]
Target gene sequencing has become increasingly available and appropriate primers have been designed and published for the most common species.
“Target gene sequencing has become increasingly available and appropriate primers designed and published for the most common species (9–15).”
From Echinocandin resistance: an emerging clinical problem? (2014) · cites this paper as [13]
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References 14 · Cited by 56
- Authors
- Fekkar, A., Meyer, I., Brossas, J. Y., Dannaoui, E., Palous, M., Uzunov, M., Nguyen, S., Leblond, V., Mazier, D., & Datry, A.
- Affiliations
- Inserm (FR)
- Pitié-Salpêtrière Hospital (FR)
- Service de Microbiologie, Unité de Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, Université Paris-Descartes, Faculté de Médecine, Paris, France
- Service d'Hématologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2013-05
- Volume
- 57
- Issue
- 5
- Pages
- 2380-2382
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC3632960
- OpenAlex
- W2087450680
- Cited by
- 56
- References
- 14
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 2 · 2018: 7 · 2017: 7 · 2016: 3 · 2015: 8 · 2014: 13 · 2013: 3
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Pfizer
- Astellas Pharma
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- echinocandin resistance, Candida kefyr, caspofungin, candidemia, fungemia, antifungal resistance
- MeSH terms
- Caspofungin, Amino Acid Sequence, Antifungal Agents, Candida, Candidiasis, Female, Fungal Proteins, Glucosyltransferases, Humans, Kluyveromyces, Middle Aged, Molecular Sequence Data, Mutation, Fatal Outcome, Drug Resistance, Fungal, Echinocandins, Lipopeptides, Candidemia
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