Novel ERG11 and TAC1b Mutations Associated with Azole Resistance in Candida auris
Open accessAbstract
Candida auris is a novel Candida species that has spread in all continents, causing nosocomial outbreaks of invasive candidiasis. C. auris has the ability to develop resistance to all antifungal drug classes. Notably, many C. auris isolates are resistant to the azole drug fluconazole, a standard therapy for invasive candidiasis.
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A previously unreported Erg11 substitution F444L was identified in azole-resistant clade IV clinical isolates of C. auris.
“with a recent study highlighting a previously unreported substitution in Erg11 (F444L) identified in azole-resistant clade IV clinical isolates that has not been previously described in other reports15.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [15]
Mutations in ERG11 contribute to reduced azole susceptibility in C. auris.
“Mutations in ERG11 also contribute to reduced azole susceptibility in the emerging fungal pathogen C. auris12–15, with a recent study highlighting a previously unreported substitution in Erg11 (F444L) identified in azole-resistant clade IV clinical isolates that has not been previously described in other reports15.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [15]
A TAC1B mutation encoding S611P is capable of conferring enhanced fluconazole resistance among clade-IV clinical isolates.
“Additional work demonstrated another TAC1B mutation (encoding S611P) capable of conferring enhanced fluconazole resistance among clade-IV clinical isolates, further highlighting that TAC1B mutations contribute to azole resistance across diverse clades15.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [15]
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References 28 · Cited by 82
Research works printed but not linked: 1
- [27]Clinical and Laboratory Standards Institute. 2017. Reference method for broth dilution antifungal susceptibility testing of yeasts, 4th ed. Document M27. Clinical and Laboratory Standards Institute, Wayne, PA. [Google Scholar]
- Authors
- Li, J., Coste, A. T., Liechti, M., Bachmann, D., Sanglard, D., & Lamoth, F.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2021-04-19
- Volume
- 65
- Issue
- 5
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC8092887
- OpenAlex
- W3132971294
- Cited by
- 82
- References
- 28
- Citations by year
- 2026: 19 · 2025: 17 · 2024: 17 · 2023: 11 · 2022: 13 · 2021: 5
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- IRIS (submittedVersion)
- Funders
- Fondation Santos-Suarez pour la Recherche Médicale
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida auris, azole resistance, fluconazole resistance, ERG11, drug resistance mutations, invasive candidiasis, antifungal resistance, hospital outbreak
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