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Avermectins, New Family of Potent Anthelmintic Agents: Producing Organism and Fermentation
Open accessAbstract
The avermectins are a complex of chemically related agents which exhibit extraordinarily potent anthelmintic activity. They are produced by a novel species of actinomycete, NRRL 8165, which we have named Streptomyces avermitilis . The morphological and cultural characteristics which differentiate the producing organism from other species are described. The avermectins have been identified as a series of macrocyclic lactone derivatives which, in contrast to the macrolide or polyene antibiotics, lack significant antibacterial or antifungal activity. The avermectin complex is fully active against the gastrointestinal nematode Nematospiroides dubius when fed to infected mice for 6 days at 0.0002% of the diet. Fermentation development, including medium modification and strain selection, resulted in increasing the broth yields from 9 to 500 μg/ml.
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Citations
Cited by
Lumaret, J.-P., Errouissi, F., Floate, K., Rombke, J., & Wardhaugh, K. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112800399257 · Cited by 367
The life and times of ivermectin — a success story
Õmura, S., & Crump, A. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1048 · Cited by 273
Self-citationCastro-Falcón, G., Millán-Aguiñaga, N., Roullier, C., Jensen, P. R., & Hughes, C. C. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00598 · Cited by 29
Metadata
- Authors
- Burg, R. W., Miller, B. M., Baker, E. E., Birnbaum, J., Currie, S. A., Hartman, R., Kong, Y.-L., Monaghan, R. L., Olson, G., Putter, I., Tunac, J. B., Wallick, H., Stapley, E. O., Oiwa, R., & Ōmura, S.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1979-03
- Volume
- 15
- Issue
- 3
- Pages
- 361-367
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2082909688
- Cited by
- 933
- References
- 0
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Burg, R. W., Miller, B. M., Baker, E. E., Birnbaum, J., Currie, S. A., Hartman, R., Kong, Y.-L., Monaghan, R. L., Olson, G., Putter, I., Tunac, J. B., Wallick, H., Stapley, E. O., Oiwa, R., & Ōmura, S. (1979). Avermectins, New Family of Potent Anthelmintic Agents: Producing Organism and Fermentation. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.15.3.361
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
