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Clinical Significance of In Vitro Synergism Between Antibiotics in Gram-Negative Infections
Open accessAbstract
Five combinations of antibiotics (ampicillin/gentamicin, cephalothin/gentamicin, carbenicillin/gentamicin, polymyxin/carbenicillin, and carbenicillin/cephalothin) were investigated in vitro and in 148 severe infectious episodes caused by gram-negative bacilli in patients with disseminated cancer. The use of combinations that were synergistic in vitro against the offending microorganism (synergy was defined as occurring when the minimal inhibitory concentration of each of the drugs in the combination was one-quarter or less of the minimal inhibitory concentration of each drug alone) was associated with a significantly better response to antibacterial therapy ( P < 0.01) than the use of combinations that were not synergistic against the causative agent.
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Citations
Cited by
Combination Therapy for Treatment of Infections with Gram-Negative Bacteria
Tamma, P. D., Cosgrove, S. E., & Maragakis, L. L. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.05041-11 · Cited by 836
White, R. L., Burgess, D. S., Manduru, M., & Bosso, J. A. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.8.1914 · Cited by 721
A Method for Testing for Synergy with Any Number of Agents
Berenbaum, M. C. (1978) · Journal of Infectious Diseases · doi:10.1093/infdis/137.2.122 · Cited by 720
Accelerated evolution of resistance in multidrug environments
Hegreness, M., Shoresh, N., Damian, D., Hartl, D., & Kishony, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805965105 · Cited by 300
Cometta, A., Calandra, T., Gaya, H., Zinner, S. H., de Bock, R., Del Favero, A., Bucaneve, G., Crokaert, F., Kern, W. V., Klastersky, J., et al. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.5.1108 · Cited by 275
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Metadata
- Authors
- Klastersky, J., Cappel, R., & Daneau, D.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1972-12
- Volume
- 2
- Issue
- 6
- Pages
- 470-475
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2118765654
- Cited by
- 186
- References
- 0
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Klastersky, J., Cappel, R., & Daneau, D. (1972). Clinical Significance of In Vitro Synergism Between Antibiotics in Gram-Negative Infections. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.2.6.470
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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