The DOI matches its Crossref record.
Antibacterial activity of matrix-bound ovotransferrin
Open accessAbstract
Ovotransferrin immobilized by covalent linkage to Sepharose 4B showed a bacteriostatic effect towards Escherichia coli similar to that of free ovotransferrin. The growth of the bacteria, after exposure to the gel-bound ovotransferrin and its removal, depended on the length of exposure. The results suggest that the antibacterial activity of transferrin is not due simply to the removal of iron from the medium.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ovotransferrin suppressed Pseudomonas sp., Escherichia coli, and Streptococcus mutans.
“Valenti et al. (1982) reported that ovotransferrin supressed Pseudomonas sp., Escherichia coli, and Streptococcus mutans.”
From Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—A review (2013) · cites this paper as Valenti et al., 1982
Citations
Cited by
Sorted by citations
Abeyrathne, E. D. N. S., Lee, H. Y., & Ahn, D. U. (2013) · Poultry Science · doi:10.3382/ps.2013-03391 · Cited by 532
“Valenti et al. (1982) reported that ovotransferrin supressed Pseudomonas sp., Escherichia coli, and Streptococcus mutans.”
BackgroundValenti, P., & Antonini, G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5372-0 · Cited by 470
Self-citationOvotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism
Ibrahim, H. R., Sugimoto, Y., & Aoki, T. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00122-7 · Cited by 319
Cuperus, T., Coorens, M., van Dijk, A. I. J. M., & Haagsman, H. P. (2013) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2013.04.019 · Cited by 203
Ovotransferrin: Structure, bioactivities, and preparation
Wu, J., & Acero-Lopez, A. (2012) · Food Research International · doi:10.1016/j.foodres.2011.07.012 · Cited by 188
Physiological roles of ovotransferrin
Giansanti, F., Leboffe, L., Pitari, G., Ippoliti, R., & Antonini, G. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.004 · Cited by 145
Self-citationGiansanti, F., Rossi, P., Massucci, M., Botti, D., Antonini, G., Valenti, P., & Seganti, L. (2002) · Biochemistry and cell biology = Biochimie et biologie cellulaire · doi:10.1139/o01-208 · Cited by 93
Self-citationAntifungal activity of ovotransferrin towards genus Candida
Valenti, P., Visca, P., Antonini, G., & Orsi, N. (1985) · Mycopathologia · doi:10.1007/bf00447027 · Cited by 87
Self-citationAntimicrobial activity of the Anseriform outer eggshell and cuticle.
Wellman-Labadie, O., Picman, J., & Hincke, M. (2008) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/j.cbpb.2008.01.001 · Cited by 80
Awade, A., Moreau, S., Mollé, D., Brûlé, G., & Maubois, J. (1994) · Journal of Chromatography A · doi:10.1016/0021-9673(94)80156-8 · Cited by 78
Wellman-Labadie, O., Picman, J., & Hincke, M. (2008) · British Poultry Science · doi:10.1080/00071660802001722 · Cited by 76
“Ovotransferrin immobilised on Sepharose 4B maintains its iron-binding capacity and its bacteriostatic activity (Valenti et al., 1982) indicating that eggshell-bound ovotransferrin could provide antimicrobial defence.”
BackgroundMa, B., Guo, Y.-X., Fu, X.-Z., & Jin, Y.-G. (2020) · LWT · doi:10.1016/j.lwt.2020.109720 · Cited by 72
Vachier, M. C., Piot, M., & Awadé, A. C. (1995) · Journal of Chromatography B: Biomedical Sciences and Applications · doi:10.1016/0378-4347(94)00411-w · Cited by 66
Synthesis, characterization, and application of Fe3O4@SiO2–NH2 nanoparticles
Liu, F., Niu, F.-G., Peng, N., Su, Y.-J., & Yang, Y.-J. (2015) · RSC Advances · doi:10.1039/c4ra15968c · Cited by 66
Functional properties of ovotransferrin from chicken egg white and its derived peptides: a review
Rathnapala, E. C. N., Ahn, D. U., & Abeyrathne, E. D. N. S. (2021) · Food Science and Biotechnology · doi:10.1007/s10068-021-00901-3 · Cited by 67
Abdel-Shafi, S., Osman, A., Enan, G., El-Nemer, M., & Sitohy, M. (2016) · SpringerPlus · doi:10.1186/s40064-016-2625-3 · Cited by 63
Shi, Y.-X., Kong, W., & Nakayama, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001518200 · Cited by 59
Zhang, X.-L., Yue, X.-J., Ma, B., Fu, X.-Z., Ren, H., & Ma, M.-H. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128905 · Cited by 56
Avian antimicrobial proteins: structure, distribution and activity
Wellman-Labadie, O., Picman, J., & Hincke, M. (2007) · World s Poultry Science Journal · doi:10.1017/s0043933907001559 · Cited by 55
“Chicken egg white ovotransferrin immobilized on Sepharose 4B maintains its iron-binding capacity and bacteriostatic activity (Valenti et al., 1982).”
BackgroundThe Nutraceutical Properties of Ovotransferrin and Its Potential Utilization as a Functional Food
Giansanti, F., Leboffe, L., Angelucci, F., & Antonini, G. (2015) · Nutrients · doi:10.3390/nu7115453 · Cited by 61
Self-citationSeparation of ovotransferrin from chicken egg white without using organic solvents
Abeyrathne, E. D. N. S., Lee, H. Y., Ham, J. S., & Ahn, D. U. (2013) · Poultry Science · doi:10.3382/ps.2012-02654 · Cited by 46
“microbial activity, and thus, can be used to improve the safety of foods (Valenti et al., 1982; Ibrahim et al., 2000; Ko et al., 2008).”
BackgroundSeparation of ovotransferrin and ovomucoid from chicken egg white
Abeyrathne, E. D. N. S., Lee, H. Y., & Ahn, D. U. (2014) · Poultry Science · doi:10.3382/ps.2013-03649 · Cited by 47
“Ovotransferrin is known to have a strong iron-binding capability, and thus can be used as an antioxidant, antimicrobial, or iron-supplementing agent (Valenti et al., 1982; Ibrahim et al., 2000; Ko et al., 2008).”
BackgroundHuman Transferrin Confers Serum Resistance against Bacillus anthracis*
Rooijakkers, S., Rasmussen, S. L., McGillivray, S., Bartnikas, T., Mason, A., Friedlander, A., & Nizet, V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.154930 · Cited by 36
Ko, K., Mendonca, A. F., & Ahn, D. U. (2008) · Poultry Science · doi:10.3382/ps.2007-00503 · Cited by 35
“Valenti et al. (1982) reported that Sepharose-bound ANTIBACTERIAL ACTIVITY OF OVOTRANSFERRIN 2667 ovotransferrin showed greater antimicrobial activity than free ovotransferrin, because matrix-bound proteins have greater stability than soluble ovotransferrin.”
BackgroundValenti, P., Visca, P., Antonini, G., Orsi, N., & Antonini, E. (2004) · Medical Microbiology and Immmunology · doi:10.1007/bf00193893 · Cited by 32
Self-citationOvotransferrin expression and release by chicken cell lines infected with Marek's disease virus.
Giansanti, F., Giardi, M. F., Massucci, M., Botti, D., & Antonini, G. (2007) · Biochemistry and cell biology = Biochimie et biologie cellulaire · doi:10.1139/o06-210 · Cited by 31
Self-citationA proteomic approach to analysis of antimicrobial activity in marsupial pouch secretions.
Ambatipudi, K., Joss, J., Raftery, M., & Deane, E. (2008) · Developmental and Comparative Immunology · doi:10.1016/j.dci.2007.04.009 · Cited by 23
Recent Advances in Applications of Bioactive Egg Compounds in Nonfood Sectors
Zhang, X., Chelliappan, B., Rajeswari, S., & Antonysamy, M. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.738993 · Cited by 22
Sequential separation of lysozyme, ovomucin, ovotransferrin, and ovalbumin from egg white.
Abeyrathne, E. D. N. S., Lee, H. Y., & Ahn, D. U. (2014) · Poultry Science · doi:10.3382/ps.2013-03403 · Cited by 20
“Ovotransferrin is well known to have a strong iron binding capability, and thus, can be used as an antimicrobial agent, antioxidant, or an iron-supplementing agent (FraenkelConrat and Feeney, 1950; Valenti et al., 1982; Ibrahim et al., 2000; Ko et al., 2009; Wu and Acer-Lopez, 2012).”
BackgroundInteraction of lactoferrin with Escherichia coli cells and correlation with antibacterial activity
Visca, P., Dalmastri, C., Verzili, D., Antonini, G., Chiancone, E., & Valenti, P. (2004) · Medical Microbiology and Immmunology · doi:10.1007/bf00189610 · Cited by 18
“coli cells by a dialysis membrane or are used in other experimental set-ups to scavenge iron from the growth medium without any contact with the bacterial cells [25, 26, 29].”
BackgroundSelf-citationA simplified rapid method for the removal of iron and other cations from complex media
Domingue, P. A. G., Mottle, B., Morck, D., Borwn, M. R. W., & Costerton, J. (1990) · Journal of Microbiological Methods · doi:10.1016/0167-7012(90)90003-o · Cited by 17
Evaluation of the prophylactic use of ovotransferrin against chlamydiosis in SPF turkeys.
van Droogenbroeck, C., Beeckman, D., Harkinezhad, T., Cox, E., & Vanrompay, D. (2008) · Veterinary Microbiology · doi:10.1016/j.vetmic.2008.05.028 · Cited by 16
“The antibacterial activity can partially involve iron sequestration (Valenti et al., 1982, 1983) and can be related to the action of OTAP-92, a short sequence located in the N-terminal domain of ovoTF (Ibrahim et al., 1998, 2000).”
BackgroundReiter, B., & Perraudin, J.-P. (1998) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4757-9068-9_21 · Cited by 11
Iron Transport Tocopheryl Polyethylene Glycol Succinate in Animal Health and Diseases
Srivastava, A., Lall, R., Talukder, J., DuBourdieu, D., & Gupta, R. C. (2019) · Molecules · doi:10.3390/molecules24234289 · Cited by 9
“[111] reported that Pseudomonas spp., Escherichia coli, and Streptococcus mutans were the most sensitive and Proteus spp. and Klebsiella spp.”
BackgroundInfluentialNaidu, A. (2014) · Natural Antimicrobials for the Minimal Processing of Foods · doi:10.1533/9781855737037.133 · Cited by 10
“…of OTF, a biocidal effect (microbial killing independent of iron deprivation) against a wide spectrum of microorganisms (e.g. Pseudomonas spp., E. coli, Streptococcus mutans, S. aureus, Proteus spp., and Klebsiella spp.) has also been suggested (Valenti et al., 1982, 1983b, 1984, 1985, 1987).”
BackgroundVaron, O., Allen, K. J., Bennett, D. C., Mesak, L. R., & Scaman, C. H. (2013) · Food Research International · doi:10.1016/j.foodres.2013.02.041 · Cited by 10
Tu, S.-I., Reed, S., Gehring, A., & He, Y.-P. (2009) · doi:10.1007/s12161-008-9033-4 · Cited by 9
Purification and Characterization of Ovotransferrin from Crocodylus siamensis
Chaipayang, S., Heamatorn, N., Keha, L., Daduang, S., Songsiriritthigul, C., Swatsitang, P., Dhiravisit, A., & Thammasirirak, S. (2013) · The Protein Journal · doi:10.1007/s10930-012-9461-2 · Cited by 5
Structural change of ovalbumin‐related protein X by alkali treatment
Akazawa, T., Ogawa, M., Hayakawa, S., Hirata, M., & Niwa, T. (2018) · Poultry Science · doi:10.3382/ps/pey024 · Cited by 4
Use of ovotransferrin on a turkey farm to reduce respiratory disease
McCartney, W., Liégey, A., MacDonald, B., Comiskey, D., & Galvin, E. (2012) · The Veterinary Record · doi:10.1136/vr.100945 · Cited by 3
Egg Derived Ovotransferrins and Lactoferrins
Talukder, J. R. (2019) · Nutraceuticals in Veterinary Medicine · doi:10.1007/978-3-030-04624-8_17 · Cited by 2
Function and Separation of Ovotransferrin from Chicken Egg
Abeyrathne, E. D. N. S., & Ahn, D. U. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800879-9.00023-8 · Cited by 1
Antimicrobial defences of the avian egg
Wellman-Labadie, O. (2008) · doi:10.20381/ruor-19797
Metadata
- Authors
- Valenti, P., Antonini, G., Fanelli, M. R., Orsi, N., & Antonini, E.
- Affiliations
- Sapienza University of Rome (IT)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1982-05
- Volume
- 21
- Issue
- 5
- Pages
- 840-841
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC182023
- OpenAlex
- W2006012705
- Cited by
- 51
- References
- 0
- Citations by year
- 2021: 3 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Iris (Roma Tre University) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- ovotransferrin, transferrin, antibacterial activity, Escherichia coli, bacteriostatic activity, protein immobilization, covalent binding, Sepharose 4B, iron removal, bactericidal mechanism
- MeSH terms
- Anti-Bacterial Agents, Conalbumin, Egg Proteins, Escherichia coli, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
