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Cited by 50Antibiotics Pharmacokinetics and EfficacyPharmaceutical studies and practicesMechanical Circulatory Support Devices

The DOI matches its Crossref record.

Pharmacokinetics of gentamicin in neonates on extracorporeal membrane oxygenation

Open access
Southgate, W M, DiPiro, J T, Robertson, A F·1989·Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.33.6.817PMC PMC284237
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Abstract

Extracorporeal membrane oxygenation (ECMO) has been used in more than 1,000 infants in 50 centers in the United States. The extracorporeal circuit contains approximately 400 ml of blood, an amount exceeding the blood volume of most full-term neonates. The effect of this additional blood volume on drug disposition is unknown. In this study, we determined the pharmacokinetic parameters of gentamicin in 10 infants on ECMO. Gentamicin concentrations were determined by a fluorescence polarization immunoassay. Pharmacokinetic parameters were determined from these concentrations by using a two-compartment model. Our study demonstrated a mean steady-state volume of distribution of 0.51 +/- 0.11 liters/kg, a figure similar to that in previous studies of full-term infants. The elimination half-life was found to be prolonged (mean, 573 +/- 263 min). The creatinine level in the plasma of the infants was found to be a statistically significant predictor of elimination half-life. Recommendations regarding initial dosing levels of gentamicin in infants on ECMO are made.

Overview

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Crossref · 10.1128/aac.33.6.817

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Metadata

Authors
Southgate, W. M., DiPiro, J. T., & Robertson, A. F.
Affiliations
Augusta University (US)
ORCID
Venue
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Published
1989-06
Volume
33
Issue
6
Pages
817-819
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
DOI
10.1128/aac.33.6.817
PMC
PMC284237
OpenAlex
W1972229533
Cited by
50
References
0
Citations by year
2024: 2 · 2023: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2014: 5 · 2013: 4 · 2012: 3
FWCI
0.40
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • VCU Scholars Compass (Virginia Commonwealth University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
Keywords
gentamicin, pharmacokinetics, extracorporeal membrane oxygenation, neonates, infants, volume of distribution, elimination half-life, creatinine, aminoglycoside dosing, two-compartment model
MeSH terms
Blood Urea Nitrogen, Creatinine, Gentamicins, Humans, Infant, Newborn, Extracorporeal Membrane Oxygenation

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.