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Cited by 399

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users

Open access
Small, P M, Chambers, H F·1990·Antimicrobial Agents and Chemotherapy

Abstract

The clinical courses of 13 consecutive intravenous drug users with Staphylococcus aureus endocarditis treated principally with vancomycin were reviewed. Two patients, one with only right-sided endocarditis and the other with tricuspid and mitral valve endocarditis, had recurrences of positive blood cultures 2 days after completing a 4-week course of vancomycin. Two patients, both of whom eventually were cured, had modifications of therapy because of bacteremia persisting 7 and 16 days into therapy. One patient required an operation for recurrent fevers, and the resected vegetation showed evidence of active infection. Time-kill studies performed with nafcillin and vancomycin for 10 isolates of S. aureus showed that vancomycin was less rapidly bactericidal than nafcillin. Although vancomycin is used as an alternative to penicillinase-resistant penicillins for treatment of staphylococcal endocarditis, these findings raise the question of whether it is equivalent to these drugs in efficacy.

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Crossref · 10.1128/aac.34.6.1227

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Metadata

Authors
Small, P. M., & Chambers, H. F.
Venue
Antimicrobial Agents and Chemotherapy
Published
1990-06
Volume
34
Issue
6
Pages
1227-1231
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W2044087791
Cited by
399
References
1
FWCI
7.35
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users. https://app.cochat.ai/papers/10.1128/aac.34.6.1227
The paper
Small, P. M., & Chambers, H. F. (1990). Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.34.6.1227

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.