The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms
Open accessAbstract
Susceptibilities to erythromycin by broth microdilution were compared with those to the newer macrolide clarithromycin for 223 isolates of rapidly growing mycobacteria belonging to seven taxonomic groups. Seventy-nine random isolates were also tested against azithromycin and roxithromycin. The MIC of clarithromycin for 90% of strains tested (MIC90) was 0.25 microgram/ml for isolates of Mycobacterium chelonae subsp. chelonae and 0.5 microgram/ml for M. chelonae subsp. abscessus, with 100% of strains inhibited by less than or equal to 1 microgram/ml. Clarithromycin was 10 to 50 times more active than erythromycin and four- to eightfold more active than the other newer macrolides against M. chelonae. MICs of clarithromycin frequently increased with prolonged incubation with isolates of M. chelonae subsp. abscessus but not M. chelonae subsp. chelonae. MICs of clarithromycin were much higher for M. fortuitum bv. fortuitum (MIC50, 2.0 microgram/ml; MIC90, greater than 8.0 microgram/ml). The three newer macrolides had comparable activity against M. fortuitum bv. peregrinum (MIC90s of 0.5 to 2.0 microgram/ml compared with erythromycin MIC90s of greater than 8.0 microgram/ml). Overall, clarithromycin was the most active agent, inhibiting all isolates of M. chelonae subsp. chelonae, M. chelonae subsp. abscessus, M. fortuitum bv. peregrinum, and the M. chelonae-like organisms and 35% of M. fortuitum bv. fortuitum at less than or equal to 1 microgram/ml. Clinical trials of the newer macrolides, especially clarithromycin, against these environmental mycobacterial species appear to be warranted.
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Cites
Spectrum of Disease Due to Rapidly Growing Mycobacteria
Wallace, R. J., Swenson, J. M., Silcox, V. A., Good, R. C., Tschen, J. A., & Stone, M. S. (1983) · Clinical Infectious Diseases · doi:10.1093/clinids/5.4.657 · Cited by 584
Self-citationWallace, R. J., Swenson, J. M., Silcox, V. A., & Bullen, M. G. (1985) · Journal of Infectious Diseases · doi:10.1093/infdis/152.3.500 · Cited by 272
Self-citationAntimicrobial susceptibility of five subgroups of Mycobacterium fortuitum and Mycobacterium chelonae
Swenson, J. M., Wallace, R. J., Silcox, V. A., & Thornsberry, C. (1985) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.28.6.807 · Cited by 258
Self-citationSwenson, J. M., Thornsberry, C., & Silcox, V. A. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.22.2.186 · Cited by 187
Mycobacterium chelonaeCausing Otitis Media in an Ear-Nose-and-Throat Practice
Lowry, P. W., Jarvis, W. R., Oberle, A. D., Bland, L. A., Silberman, R., Bocchini, J. A., Dean, H. D., Swenson, J. M., & Wallace, R. J. (1988) · New England Journal of Medicine · doi:10.1056/nejm198810133191504 · Cited by 187
Self-citationIdentification of clinically significant Mycobacterium fortuitum complex isolates
Silcox, V. A., Good, R. C., & Floyd, M. M. (1981) · Journal of Clinical Microbiology · doi:10.1128/jcm.14.6.686-691.1981 · Cited by 172
In vitro and in vivo activities of clarithromycin against Mycobacterium avium
FERNANDES, P. B., Hardy, D. J., McDaniel, D., Hanson, C. W., & Swanson, R. N. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.9.1531 · Cited by 158
Dalovisio, J. R., Pankey, G. A., Wallace, R. J., & Jones, D. B. (1981) · Clinical Infectious Diseases · doi:10.1093/clinids/3.5.1068 · Cited by 122
Self-citationBarry, A. L., Jones, R. N., & Thornsberry, C. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.5.752 · Cited by 111
Wallace, R. J., Brown, B. A., & Onyi, G. O. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.4.773 · Cited by 102
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Cited by
Griffith, D. E., Aksamit, T., Brown-Elliott, B. A., Catanzaro, A., Daley, C., Gordin, F., Holland, S. M., Horsburgh, R., Huitt, G., Iademarco, M. F., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200604-571st · Cited by 6,110
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Metadata
- Authors
- Brown, B. A., Wallace, R. J., Onyi, G. O., De Rosas, V, & Wallace, R. J.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1992-01
- Volume
- 36
- Issue
- 1
- Pages
- 180-184
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W1985859896
- Cited by
- 301
- References
- 12
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms. https://app.cochat.ai/papers/10.1128/aac.36.1.180
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- Brown, B. A., Wallace, R. J., Onyi, G. O., De Rosas, V, & Wallace, R. J. (1992). Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.36.1.180
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