The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro
Open accessAbstract
Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.
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Cites
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The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
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Mitsuya, H., Weinhold, K. J., Furman, P. A., St Clair, M. H., Lehrman, S. N., Gallo, R. C., Bolognesi, D., Barry, D. W., & Broder, S. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.20.7096 · Cited by 1,866
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
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Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus
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Cited by
Coates, J. A., Cammack, N., Jenkinson, H. J., Jowett, A. J., Jowett, M. I., Pearson, B. A., Penn, C. R., Rouse, P. L., Viner, K. C., & Cameron, J. M. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.4.733 · Cited by 240
Self-citationMimtsoudis, I., Tsachouridou, O., Akinosoglou, K., & Metallidis, S. (2024) · Viruses · doi:10.3390/v16091392 · Cited by 13
Metadata
- Authors
- Coates, J. A., Cammack, N., Jenkinson, H. J., Mutton, I. M., Pearson, B. A., Storer, R., Cameron, J. M., & Penn, C. R.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1992-01
- Volume
- 36
- Issue
- 1
- Pages
- 202-205
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2040962830
- Cited by
- 288
- References
- 11
- FWCI
- 27.86
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro. https://app.cochat.ai/papers/10.1128/aac.36.1.202
- The paper
- Coates, J. A., Cammack, N., Jenkinson, H. J., Mutton, I. M., Pearson, B. A., Storer, R., Cameron, J. M., & Penn, C. R. (1992). The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.36.1.202
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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