The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
(-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro
Open accessAbstract
The (-)-enantiomer of 2'-deoxy-3'-thiacytidine (3TC) was found to be a potent and selective inhibitor of human immunodeficiency virus types 1 (HIV-1) and 2 (HIV-2) in vitro. We determined its antiviral activity against a number of laboratory strains of HIV-1 and HIV-2 in a range of CD4-bearing lymphocyte cell lines (mean 50% inhibitory concentration [IC50] range, 4 nM to 0.67 microM). 3TC was also active against a range of HIV-1 strains in peripheral blood lymphocytes (mean IC50 range, 2.5 to 90 nM). The IC50 for cytotoxicity in seven lymphocyte cell cultures, including human peripheral blood lymphocytes, ranged from 0.5 to 6 mM. 3TC had no detectable antiviral activity against a range of other viruses or in cells chronically infected with HIV-1 or HIV-2. The effects of time of addition of the compound and varying the multiplicity of infection on the antiviral activity of 3TC were determined. The results showed that 3TC is a potent and selective inhibitor of HIV-1 and HIV-2 replication in vitro.
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“3TC (Lamivudine) is a water-soluble nucleoside analog inhibitor of reverse transcriptase38”
From Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies (2018) · cites this paper as [38]
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“that is FDA-approved for treatment of HIV/AIDS and Hepatitis B, both of which are caused by retroviruses”
From Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies (2018) · cites this paper as [38]
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Cites
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Tisdale, M., Kemp, S. D., Parry, N. R., & Larder, B. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5653 · Cited by 603
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Self-citation
Metadata
- Authors
- Coates, J. A., Cammack, N., Jenkinson, H. J., Jowett, A. J., Jowett, M. I., Pearson, B. A., Penn, C. R., Rouse, P. L., Viner, K. C., & Cameron, J. M.
- Affiliations
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1992-04
- Volume
- 36
- Issue
- 4
- Pages
- 733-739
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC189378
- OpenAlex
- W2001967406
- Cited by
- 240
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2022: 2 · 2020: 4 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Keywords
- zalcitabine, HIV-1, HIV-2, antiviral activity, HIV replication inhibition, enantiomers, peripheral blood lymphocytes, cytotoxicity, drug selectivity
- MeSH terms
- Cells, Cultured, Humans, RNA-Directed DNA Polymerase, Tritium, Virus Replication, Zidovudine, HIV-1, HIV-2, Giant Cells, Zalcitabine, Didanosine, Cell Death, Lamivudine, HIV Reverse Transcriptase
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