Trimethoprim and sulfonamide resistance.
Open accessAbstract
Free access1 February 1995 Share on Trimethoprim and sulfonamide resistanceAuthors: P Huovinen, L Sundström, G Swedberg, O SköldAuthors Info & AffiliationsDOI: https://doi.org/10.1128/AAC.39.2.279 PDF/EPUB
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Some strains of Neisseria meningitidis have acquired a DHPS gene with 10% sequence divergence, postulated by others to be due to recombination.
“For example, some strains of Neisseria meningitidis have acquired a DHPS gene with 10% sequence divergence, postulated by others to be due to recombination (12), whereas other Neisseria strains have acquired a chromosomal insertion, resulting in the addition of two amino acids to DHPS (13).”
From Dihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance (2004) · cites this paper as [12]
In most gram-negative enteric bacteria, sulfonamide resistance is largely plasmid-borne and related to drug-resistant DHPS variants with substantial sequence divergence.
“In most gram-negative enteric bacteria, sulfonamide resistance is largely plasmid-borne and related to drug-resistant DHPS variants with substantial sequence divergence (12).”
From Dihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance (2004) · cites this paper as [12]
Resistance to sulfonamides can emerge by means of a number of mechanisms.
“Resistance to sulfonamides can emerge by means of a number of mechanisms (12).”
From Dihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance (2004) · cites this paper as [12]
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Self-citationDihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance
Huang, L., Crothers, K., Atzori, C., Benfield, T., Miller, R., Rabodonirina, M., & Helweg-Larsen, J. (2004) · Emerging Infectious Diseases · doi:10.3201/eid1010.030994 · Cited by 131 · see citing works
“In most gram-negative enteric bacteria, sulfonamide resistance is largely plasmidborne and related to drug-resistant DHPS variants with substantial sequence divergence (12).”
BackgroundInfluentialSchafer, F., Fich, F., Lam, M., Gárate, C., Wozniak, A., & Garcia, P. (2013) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2011.05371.x · Cited by 76 · see citing works
- Authors
- Huovinen, P., Sundström, L., Swedberg, G., & Sköld, O.
- Affiliations
- Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1995-02
- Volume
- 39
- Issue
- 2
- Pages
- 279-289
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC162528
- OpenAlex
- W2154858303
- Cited by
- 523
- References
- 0
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 17 · 2023: 12 · 2022: 16 · 2021: 19 · 2020: 21 · 2019: 24 · 2018: 21 · 2017: 24 · 2016: 27 · 2015: 20 · 2014: 17 · 2013: 13 · 2012: 16
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- trimethoprim, sulfonamide resistance, antimicrobial resistance, drug resistance mechanisms, bacterial resistance
- MeSH terms
- Amino Acid Sequence, Animals, Conjugation, Genetic, Drug Resistance, Microbial, Humans, Molecular Sequence Data, Plasmids, Sulfonamides, Tetrahydrofolate Dehydrogenase, Trimethoprim Resistance
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