The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors
Open accessAbstract
We evaluated the antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. A number of vinyl sulfones strongly inhibited falcipain, a Plasmodium falciparum cysteine proteinase that is a critical hemoglobinase. In studies of cultured parasites, nanomolar concentrations of three vinyl sulfones inhibited parasite hemoglobin degradation, metabolic activity, and development. The antimalarial effects correlated with the inhibition of falcipain. Our results suggest that vinyl sulfones or related cysteine proteinase inhibitors may have promise as antimalarial agents.
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Citations
Cites
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum
Rosenthal, P. J., McKerrow, J. H., Aikawa, M., Nagasawa, H., & Leech, J. H. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113766 · Cited by 331
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Powers, J. C., Asgian, J. L., Ekici, Ö. D., & James, K. E. (2002) · Chemical Reviews · doi:10.1021/cr010182v · Cited by 1,090
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O'Neill, P. M., & Posner, G. H. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030571c · Cited by 538
Metadata
- Authors
- Rosenthal, P. J., Olson, J. E., Lee, G. K., Palmer, J. T., Klaus, J. L., & Rasnick, D.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1996-07
- Volume
- 40
- Issue
- 7
- Pages
- 1600-1603
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2131316262
- Cited by
- 189
- References
- 1
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Rosenthal, P. J., Olson, J. E., Lee, G. K., Palmer, J. T., Klaus, J. L., & Rasnick, D. (1996). Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.40.7.1600
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
