The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Randomized Comparison of Artemether-Benflumetol and Artesunate-Mefloquine in Treatment of MultidrugResistant Falciparum Malaria
Open accessAbstract
An open, randomized comparison of artemether-benflumetol (CGP 56 697; Novartis) with artesunate-mefloquine was conducted in 617 patients with acute uncomplicated multidrug-resistant falciparum malaria on the western border of Thailand. Both treatments rapidly and reliably cleared fever and parasitemia, and there was no significant difference in the initial therapeutic response parameters. Parasite genotyping was used to distinguish recrudescences from new infections. The 63-day cure rate for artesunate-mefloquine (94%) was significantly higher than the cure rate for artemether-benflumetol (81%) ( P < 0.001). Both regimens were well tolerated. Nausea, vomiting, dizziness, sleep disorders, and other neurological side effects were between two and four times more common in the artesunate-mefloquine group than in the artemether-benflumetol group ( P < 0.001). Artemether-benflumetol is effective and very well tolerated in the treatment of multidrug-resistant falciparum malaria. A higher dose than that used in the present study may improve efficacy.
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Citations
Cites
The epidemiology of malaria in a Karen population on the western border of Thailand.
Luxemburger, C., Thwai, K. L., White, N. J., Webster, H. K., Kyle, D. E., Maelankirri, L., Chongsuphajaisiddhi, T., & Nosten, F. (1996) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(96)90102-9 · Cited by 233
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Cited by
Artemisinin: mechanisms of action, resistance and toxicity
Meshnick, S. R. (2002) · International Journal for Parasitology · doi:10.1016/s0020-7519(02)00194-7 · Cited by 720
White, N., Nosten, F., Looareesuwan, S., Watkins, W., Marsh, K., Snow, R., Kokwaro, G., Ouma, J., Hien, T., Molyneux, M., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)07367-x · Cited by 543
Self-citationArtemisinin drugs in the treatment of malaria: from medicinal herb to registered medication
van Agtmael, M. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01302-4 · Cited by 346
Price, R. N., Uhlemann, A.-C., van Vugt, M., Brockman, A., Hutagalung, R., Nair, S., Nash, D., Singhasivanon, P., Anderson, T. J. C., Krishna, S., et al. (2006) · Clinical Infectious Diseases · doi:10.1086/503423 · Cited by 317
Self-citationBrockman, A., Price, R. N., van Vugt, M., Heppner, D. G., Walsh, D., Sookto, P., Wimonwattrawatee, T., Looareesuwan, S., White, N. J., & Nosten, F. (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90080-4 · Cited by 185
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Metadata
- Authors
- van Vugt, M., Brockman, A., Gemperli, B., Luxemburger, C., Gathmann, I., Royce, C., Slight, T., Looareesuwan, S., White, N. J., & Nosten, F.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1998-01
- Volume
- 42
- Issue
- 1
- Pages
- 135-139
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W1941644877
- Cited by
- 170
- References
- 1
- FWCI
- 18.69
- Type
- journal article
- Language
- en
- Open access
- green
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- van Vugt, M., Brockman, A., Gemperli, B., Luxemburger, C., Gathmann, I., Royce, C., Slight, T., Looareesuwan, S., White, N. J., & Nosten, F. (1998). Randomized Comparison of Artemether-Benflumetol and Artesunate-Mefloquine in Treatment of MultidrugResistant Falciparum Malaria. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.42.1.135
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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