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Sequence Analysis of ARI-1, a Novel OXA β-Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92

Open access
Donald, Helen M., Scaife, Wendy, Amyes, Sebastian G. B., Young, Hilary-Kay·2000·Antimicrobial Agents and Chemotherapy

Abstract

The sequence of the bla ARI-1 gene from imipenem-resistant Acinetobacter baumannii 6B92 has been determined. The structural gene encodes a 273-amino-acid protein which is most related to the OXA class D β-lactamases. The conserved S-T-F-K and K-T-G motifs were identified in the ARI-1 protein sequence, also named OXA-23, but significantly, a point mutation (Y→F) was identified in the Y-G-N conserved motif, also known to function in the active site.

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Metadata

Authors
Donald, H. M., Scaife, W., Amyes, S. G. B., & Young, H.-K.
Venue
Antimicrobial Agents and Chemotherapy
Published
2000-01
Volume
44
Issue
1
Pages
196-199
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W3023926866
Cited by
235
References
0
FWCI
6.71
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Sequence Analysis of ARI-1, a Novel OXA β-Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92. https://app.cochat.ai/papers/10.1128/aac.44.1.196-199.2000
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Donald, H. M., Scaife, W., Amyes, S. G. B., & Young, H.-K. (2000). Sequence Analysis of ARI-1, a Novel OXA β-Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.44.1.196-199.2000

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.