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Sequence Analysis of ARI-1, a Novel OXA β-Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92
Open accessAbstract
The sequence of the bla ARI-1 gene from imipenem-resistant Acinetobacter baumannii 6B92 has been determined. The structural gene encodes a 273-amino-acid protein which is most related to the OXA class D β-lactamases. The conserved S-T-F-K and K-T-G motifs were identified in the ARI-1 protein sequence, also named OXA-23, but significantly, a point mutation (Y→F) was identified in the Y-G-N conserved motif, also known to function in the active site.
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Poirel, L., & Nordmann, P. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01456.x · Cited by 1,051
Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity
Fisher, J. F., Meroueh, S. O., & Mobashery, S. (2005) · Chemical Reviews · doi:10.1021/cr030102i · Cited by 913
Diversity, Epidemiology, and Genetics of Class D β-Lactamases
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Metadata
- Authors
- Donald, H. M., Scaife, W., Amyes, S. G. B., & Young, H.-K.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2000-01
- Volume
- 44
- Issue
- 1
- Pages
- 196-199
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W3023926866
- Cited by
- 235
- References
- 0
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Donald, H. M., Scaife, W., Amyes, S. G. B., & Young, H.-K. (2000). Sequence Analysis of ARI-1, a Novel OXA β-Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.44.1.196-199.2000
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