Upregulation of ERG Genes in Candida Species by Azoles and Other Sterol Biosynthesis Inhibitors

Infections due to Candida albicans are usually treated with azole antifungals such as fluconazole, but treatment failure is not uncommon especially in immunocompromised individuals. Relatedly, in vitro studies demonstrate that azoles are nonfungicidal, with continued growth at strain-dependent ra…