Postantifungal Effects of Echinocandin, Azole, and Polyene Antifungal Agents against Candida albicans and Cryptococcus neoformans
Open accessAbstract
The postantifungal effect (PAFE) of fluconazole, MK-0991, LY303366, and amphotericin B was determined against isolates of Candida albicans and Cryptococcus neoformans . Concentrations ranging from 0.125 to 4 times the MIC were tested following exposure to the antifungal for 0.25 to 1 h. Combinations of azole and echinocandin antifungals (MK-0991 and LY303366) were tested against C. neoformans . Fluconazole displayed no measurable PAFE against Candida albicans or Cryptococcus neoformans , either alone or in combination with either echinocandin antifungal. MK-0991, LY303366, and amphotericin B displayed a prolonged PAFE of greater than 12 h against Candida spp. when tested at concentrations above the MIC for the organism and 0 to 2 h when tested at concentrations below the MIC for the organism.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Amphotericin B exposure results in prolonged growth inhibition (postantifungal effect).
“These models have also shown that growth inhibition after amphotericin B exposure continues for long periods of time.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [133]
Observations from pharmacodynamic studies with fluconazole and voriconazole demonstrated time-dependent antifungal activity optimal at concentrations 1 to 2 times the MIC.
“Observations from these investigations demonstrated time-dependent antifungal activity that was optimal at concentrations 1 to 2 times the MIC.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [133]
C. glabrata has emerged as an important opportunistic fungal pathogen in the United States.
“C. glabrata has undoubtedly emerged as an important opportunistic fungal pathogen in the United States (76, 90, 145, 209, 216, 240, 292).”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [76]
The citation lists haven’t been fetched yet
References 11 · Cited by 181
- Authors
- Ernst, E. J., Klepser, M. E., & Pfaller, M. A.
- Affiliations
- University of Iowa (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2000-04
- Volume
- 44
- Issue
- 4
- Pages
- 1108-1111
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC89826
- OpenAlex
- W2136377130
- Cited by
- 181
- References
- 11
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 6 · 2012: 5
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- Candida albicans, Cryptococcus neoformans, echinocandins, azole antifungals, polyene antibiotics, fluconazole, amphotericin B, combination antifungal therapy, minimum inhibitory concentration
- MeSH terms
- Caspofungin, Anidulafungin, Amphotericin B, Anti-Bacterial Agents, Antifungal Agents, Azoles, Candida albicans, Cryptococcus neoformans, Microbial Sensitivity Tests, Peptides, Peptides, Cyclic, Polyenes, Fluconazole, Echinocandins, Lipopeptides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
