Endogenous Reactive Oxygen Species Is an Important Mediator of Miconazole Antifungal Effect

Kobayashi, Daisuke; Kondo, Kei; Uehara, Nobuyuki; Otokozawa, Seiko; Tsuji, Naoki; Yagihashi, Atsuhito; Watanabe, Naoki

doi:10.1128/aac.46.10.3113-3117.2002

Endogenous Reactive Oxygen Species Is an Important Mediator of Miconazole Antifungal Effect

We investigated the significance of endogenous reactive oxygen species (ROS) produced by fungi treated with miconazole. ROS production in Candida albicans was measured by a real-time fluorogenic assay. The level of ROS production was increased by miconazole at the MIC (0.125 μg/ml) and was enhanc…