Gene Dosage and Linezolid Resistance in Enterococcus faecium and Enterococcus faecalis
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Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. We analyzed nine clinical isolates of linezolid-resistant enterococci and showed a clear association between the number of 23S rRNA genes containing this mutation and the level of linezolid resistance expressed.
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Because bacteria carry multiple copies of the 23S rRNA genes, linezolid-resistance mutations need to accumulate in multiple alleles to yield a clinically relevant phenotype, a gene-dose effect.
“Importantly, since bacteria carry multiple copies of the 23S rRNA genes, mutations need to accumulate in multiple alleles to yield a clinically relevant phenotype (gene-dose effect) (61).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [61]
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References 10 · Cited by 263
- Authors
- Marshall, S. H., Donskey, C. J., Hutton-Thomas, R., Salata, R. A., & Rice, L. B.
- Affiliations
- Louis Stokes Cleveland VA Medical Center (US)
- Case Western Reserve University (US)
- Research and Medical Services, Department of Veterans Affairs Medical Center and Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio
- Corresponding author
- Rice, L. B.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2002-10
- Volume
- 46
- Issue
- 10
- Pages
- 3334-3336
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC128780
- OpenAlex
- W2053191156
- Cited by
- 263
- References
- 10
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 8 · 2023: 11 · 2022: 10 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 9 · 2015: 13 · 2014: 20 · 2013: 4 · 2012: 14
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- linezolid resistance, Enterococcus faecium, Enterococcus faecalis, 23S rRNA gene, gene dosage, domain V, clinical isolates, macrolide resistance
- MeSH terms
- Linezolid, Acetamides, Humans, Mutation, RNA, Ribosomal, 23S, Enterococcus faecalis, Polymerase Chain Reaction, Enterococcus faecium, Gene Dosage, Genes, rRNA, Oxazolidinones, Drug Resistance, Bacterial
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