Effect of Lamivudine on Transmission of Human T-Cell Lymphotropic Virus Type 1 to Adult Peripheral Blood Mononuclear Cells In Vitro
Open accessAbstract
The effects of lamivudine (3TC) on in vitro infection of peripheral blood mononuclear cells (PBMC) from healthy donors with human T-cell lymphotropic virus type 1 (HTLV-1) were investigated. Direct measures of viral replication (viral DNA, RNA, and protein) all gave similar, very high 50% inhibitory concentrations in comparison with those previously reported for zidovudine. Nevertheless, 3TC inhibited HTLV-1-driven long-term growth of infected PBMC in vitro at concentrations (6.25 μM) which had poor or no direct antiviral effects, suggesting that another mechanism may be playing a role.
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HTLV-1 resistance to 3TC was confirmed by multiple in vitro assays.
“HTLV-1 resistance to 3TC was shortly confirmed by multiple in vitro assays [182]”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [182]
The antiviral potency of 3TC was determined to be more than 100 times lower than AZT, discounting its potential for clinical relevancy.
“and the antiviral potency was determined to be more than 100 times lower than AZT, discounting its potential for clinical relevancy.”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [182]
Cites
Coates, J. A., Cammack, N., Jenkinson, H. J., Jowett, A. J., Jowett, M. I., Pearson, B. A., Penn, C. R., Rouse, P. L., Viner, K. C., & Cameron, J. M. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.4.733 · Cited by 240 · see citing works
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Taylor, G. P., Goon, P., Furukawa, Y., Green, H., Barfield, A., Mosley, A., Nose, H., Babiker, A., Rudge, P., Usuku, K., et al. (2006) · Retrovirology · doi:10.1186/1742-4690-3-63 · Cited by 117 · see citing works
Current State of Therapeutics for HTLV-1
Wang, T. T., Hirons, A., Doerflinger, M., Morris, K. V., Ledger, S., Purcell, D. F. J., Kelleher, A. D., & Ahlenstiel, C. L. (2024) · Viruses · doi:10.3390/v16101616 · Cited by 22 · see citing works
“This will be discussed further in Section 2.2.”
BackgroundInfluential
- Authors
- Balestrieri, E., Forte, G., Matteucci, C., Mastino, A., & Macchi, B.
- Affiliations
- University of Messina (IT)
- Department of Neuroscience
- University of Rome Tor Vergata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2002-09
- Volume
- 46
- Issue
- 9
- Pages
- 3080-3083
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC127437
- OpenAlex
- W2116093796
- Cited by
- 33
- References
- 1
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 3 · 2018: 3 · 2017: 1 · 2013: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- lamivudine, zidovudine, HTLV-1, peripheral blood mononuclear cells, virus transmission, antiviral activity, viral replication inhibition, cell growth inhibition, HIV reverse transcriptase inhibitors
- MeSH terms
- DNA, Viral, Deltaretrovirus Infections, Humans, Monocytes, Virus Replication, Human T-lymphotropic virus 1, Coculture Techniques, Lamivudine, Anti-HIV Agents
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