Effects of 16S rRNA Gene Mutations on Tetracycline Resistance in Helicobacter pylori
Open accessAbstract
The triple-base-pair 16S rDNA mutation AGA 926-928 →TTC mediates high-level tetracycline resistance in Helicobacter pylori . In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.
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Mutations G966U and G1058C cause high levels of resistance to tetracycline.
“Previous studies have shown that mutations G966U and G1058C cause high levels of resistance to tetracycline (22 -24).”
From Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors (2016) · cites this paper as [23]
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References 15 · Cited by 75
- Authors
- Gerrits, M. M., Berning, M., Van Vliet, A. H. M., Kuipers, E. J., & Kusters, J. G.
- Affiliations
- Erasmus MC (NL)
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
- Corresponding author
- Kusters, Johannes G.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2003-09
- Volume
- 47
- Issue
- 9
- Pages
- 2984-2986
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC182601
- OpenAlex
- W2139903546
- Cited by
- 75
- References
- 15
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 6 · 2012: 1
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Helicobacter pylori, tetracycline resistance, 16S rRNA gene, point mutations, antibiotic resistance mechanisms, bacterial growth rate, low-level resistance
- MeSH terms
- Cloning, Molecular, Mutation, RNA, Ribosomal, 16S, Tetracycline Resistance, Mutagenesis, Site-Directed, Helicobacter pylori, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction
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