The DOI matches its Crossref record; 33 of the 35 references it cites were found in a registry or an index.
Atomic Force Microscopy Study of the Effect of Antimicrobial Peptides on the Cell Envelope of Escherichia coli
Open accessAbstract
The influences of the antibacterial magainin 2 and PGLa from the African clawed frog (Xenopus laevis) and the hemolytic bee venom melittin on Escherichia coli as the target cell were studied by atomic force microscopy (AFM). Nanometer-scale images of the effects of the peptides on this gram-negative bacterium's cell envelope were obtained in situ without the use of fixing agents. These high-resolution AFM images of the surviving and intact target cells before and after peptide treatment showed distinct changes in cell envelope morphology as a consequence of peptide action. Although all three peptides are lytic to E. coli, it is clear from this AFM study that each peptide causes distinct morphological changes in the outer membrane and in some cases the inner membrane, probably as a consequence of different mechanisms of action.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The morphological changes of some strains after carvacrol contact were comparable to those described after treatment with other antimicrobial agents, such as antimicrobial peptides [119].”
From Effect of essential oils on pathogenic bacteria (2013) · cites this paper as [119]
Citations
Cites
Zasloff, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5449 · Cited by 2,305
Habermann, E. (1972) · Science · doi:10.1126/science.177.4046.314 · Cited by 1,570
Barrel-Stave Model or Toroidal Model? A Case Study on Melittin Pores
Yang, L., Harroun, T. A., Weiss, T. M., Ding, L., & Huang, H. W. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75802-x · Cited by 1,114
Hancock, R. E. W. (1997) · The Lancet · doi:10.1016/s0140-6736(97)80051-7 · Cited by 1,098
Mode of action of linear amphipathic α-helical antimicrobial peptides
Ziv, O., & Shai, Y. (1998) · Biopolymers · doi:10.1002/(sici)1097-0282(1998)47:6 · Cited by 857
The actions of melittin on membranes
Dempsey, C. E. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90006-x · Cited by 852
Membrane Pores Induced by Magainin
Ludtke, S. J., He, K. F., Heller, W. T., Harroun, T. A., Yang, L., & Huang, H. W. (1996) · Biochemistry · doi:10.1021/bi9620621 · Cited by 804
Dathe, M., & Wieprecht, T. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00201-1 · Cited by 760
Wu, M., Maier, E., Benz, R., & Hancock, R. E. W. (1999) · Biochemistry · doi:10.1021/bi9826299 · Cited by 737
Matsuzaki, K., Murase, O., Fujii, N., & Miyajima, K. (1996) · Biochemistry · doi:10.1021/bi960016v · Cited by 724
Research works printed but not linked: 2
- 10.1021/bi035130 · DOI
- Rautenbach, M., and J. W. Hastings. 1999. Cationic peptides with antimicrobial activity—the new generation of antibiotics? Chim. Oggi/Chem. Today Nov./Dec.:81-89.
Cited by
Sorted by citations
Effect of essential oils on pathogenic bacteria
Nazzaro, F., Fratianni, F., De Martino, L., Coppola, R., & De Feo, V. (2013) · Pharmaceuticals · doi:10.3390/ph6121451 · Cited by 2,186
“The morphological changes of some strains after carvacrol contact were comparable to those described after treatment with other antimicrobial agents, such as antimicrobial peptides [119].”
ResultRole of lipids in the interaction of antimicrobial peptides with membranes
Teixeira, V., Feio, M. J., & Bastos, M. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.12.005 · Cited by 710
Hartmann, M., Berditsch, M., Hawecker, J., Ardakani, M. F., Gerthsen, D., & Ulrich, A. S. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00124-10 · Cited by 544
Sivakumar, D., & Bautista‐Baños, S. (2014) · Crop Protection · doi:10.1016/j.cropro.2014.05.012 · Cited by 469
Rai, A., Prabhune, A. A., & Perry, C. C. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm00817f · Cited by 449
Metadata
- Authors
- Meincken, M., Holroyd, D. L., & Rautenbach, M.
- Affiliations
- Stellenbosch University (ZA)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2005-10
- Volume
- 49
- Issue
- 10
- Pages
- 4085-4092
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC1251503
- OpenAlex
- W2089546856
- Cited by
- 192
- References
- 35
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 9 · 2019: 10 · 2018: 14 · 2017: 11 · 2016: 17 · 2015: 7 · 2014: 9 · 2013: 13 · 2012: 10
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- antimicrobial peptides, Escherichia coli, cell envelope, magainin 2, PGLa, melittin, outer membrane, inner membrane, membrane morphology, peptide-membrane interactions, Gram-negative bacteria, in situ imaging
- MeSH terms
- Animals, Anti-Bacterial Agents, Escherichia coli, Melitten, Xenopus laevis, Microscopy, Atomic Force, Antimicrobial Cationic Peptides, Xenopus Proteins, Magainins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
