Attenuation of the Activity of Caspofungin at High Concentrations against Candida albicans : Possible Role of Cell Wall Integrity and Calcineurin Pathways
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Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 microg/ml. This phenomenon was markedly attenuated in a deltamkc1/deltamkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these caspofungin concentrations resulted in MKC1 up-regulation, suggesting roles of cell wall integrity and calcineurin pathways.
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Inhibition of calcineurin can block the paradoxical growth of C. albicans observed at elevated echinocandin concentrations.
“Second, inhibition of calcineurin can block the paradoxical growth of C. albicans observed at elevated echinocandin concentrations [29].”
From Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin (2009) · cites this paper as [29]
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References 25 · Cited by 131
- Authors
- Wiederhold, N. P., Kontoyiannis, D. P., Prince, R. A., & Lewis, R. E.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Wiederhold, Nathan P.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2005-12
- Volume
- 49
- Issue
- 12
- Pages
- 5146-5148
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC1315970
- OpenAlex
- W2027546225
- Cited by
- 131
- References
- 25
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 12 · 2012: 8
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- caspofungin, Candida albicans, antifungal resistance, cell wall integrity pathway, calcineurin pathway, cyclosporine, antifungal susceptibility
- MeSH terms
- Caspofungin, Antifungal Agents, Candida albicans, Cell Wall, Drug Resistance, Microbial, Microbial Sensitivity Tests, Peptides, Cyclic, Gene Expression Regulation, Fungal, Calcineurin, Echinocandins, Lipopeptides, Calcineurin Inhibitors
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