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Incidence of Class 1 Integrons in a Quaternary Ammonium Compound-Polluted Environment
Open accessAbstract
Samples of effluent and soil were collected from a reed bed system used to remediate liquid waste from a wool finishing mill with a high use of quaternary ammonium compounds (QACs) and were compared with samples of agricultural soils. Resistance quotients of aerobic gram-negative and gram-positive bacteria to ditallowdimethylammomium chloride (DTDMAC) and cetyltrimethylammonium bromide (CTAB) were established by plating onto nutrient agar containing 5 μg/ml or 50 μg/ml DTDMAC or CTAB. Approximately 500 isolates were obtained and screened for the presence of the intI1(class 1 integrase),qacE(multidrug efflux), and qacEΔ1(attenuated qacE) genes. QAC resistance was higher in isolates from reed bed samples, and class 1 integron incidence was significantly higher for populations that were preexposed to QACs. This is the first study to demonstrate that QAC selection in the natural environment has the potential to coselect for antibiotic resistance, as class 1 integrons are well-established vectors for cassette genes encoding antibiotic resistance.
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Citations
Cited by
Antibiotic resistance in the environment
Larsson, D. G. J., & Flach, C.-F. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00649-x · Cited by 3,164
Antimicrobial Resistance in ESKAPE Pathogens
De Oliveira, D. M. P., Forde, B. M., Kidd, T. J., Harris, P. N. A., Schembri, M. A., Beatson, S. A., Paterson, D. L., & Walker, M. J. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00181-19 · Cited by 2,078
Environmental pollution by antibiotics and by antibiotic resistance determinants
Martinez, J. L. (2009) · Environmental Pollution · doi:10.1016/j.envpol.2009.05.051 · Cited by 1,912
Wellington, E. M., Boxall, A. B., Cross, P., Feil, E. J., Gaze, W. H., Hawkey, P. M., Johnson-Rollings, A. S., Jones, D. L., Lee, N. M., Otten, W., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70317-1 · Cited by 1,122
Self-citationThe changing epidemiology of resistance
Hawkey, P. M., & Jones, A. M. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp256 · Cited by 773
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Metadata
- Authors
- Gaze, W. H., Abdouslam, N., Hawkey, P. M., & Wellington, E. M. H.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2005-05
- Volume
- 49
- Issue
- 5
- Pages
- 1802-1807
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2110832145
- Cited by
- 245
- References
- 0
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Gaze, W. H., Abdouslam, N., Hawkey, P. M., & Wellington, E. M. H. (2005). Incidence of Class 1 Integrons in a Quaternary Ammonium Compound-Polluted Environment. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.49.5.1802-1807.2005
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