The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Ocean as a Global Reservoir of Antibiotic Resistance Genes
Open accessAbstract
Recent studies of natural environments have revealed vast genetic reservoirs of antibiotic resistance (AR) genes. Soil bacteria and human pathogens share AR genes, and AR genes have been discovered in a variety of habitats. However, there is little knowledge about the presence and diversity of AR genes in marine environments and which organisms host AR genes. To address this, we identified the diversity of genes conferring resistance to ampicillin, tetracycline, nitrofurantoin, and sulfadimethoxine in diverse marine environments using functional metagenomics (the cloning and screening of random DNA fragments). Marine environments were host to a diversity of AR-conferring genes. Antibiotic-resistant clones were found at all sites, with 28% of the genes identified as known AR genes (encoding beta-lactamases, bicyclomycin resistance pumps, etc.). However, the majority of AR genes were not previously classified as such but had products similar to proteins such as transport pumps, oxidoreductases, and hydrolases. Furthermore, 44% of the genes conferring antibiotic resistance were found in abundant marine taxa (e.g., Pelagibacter , Prochlorococcus , and Vibrio ). Therefore, we uncovered a previously unknown diversity of genes that conferred an AR phenotype among marine environments, which makes the ocean a global reservoir of both clinically relevant and potentially novel AR genes.
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Cites
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 1×
“Covering 70% of Earth’s surface area, oceans host on the order of 10(29) bacterial cells (32).”
BackgroundAntibiotic resistance is ancient
D’Costa, V. M., King, C. E., Kalan, L., Morar, M., Sung, W. W. L., Schwarz, C., Froese, D., Zazula, G., Calmels, F., Debruyne, R., et al. (2011) · Nature · doi:10.1038/nature10388 · Cited by 2,720
The shared antibiotic resistome of soil bacteria and human pathogens
Forsberg, K. J., Reyes, A., Wang, B., Selleck, E. M., Sommer, M. O. A., & Dantas, G. (2012) · Science · doi:10.1126/science.1220761 · Cited by 1,650
Functional characterization of the antibiotic resistance reservoir in the human microflora
Sommer, M. O. A., Dantas, G., & Church, G. M. (2009) · Science · doi:10.1126/science.1176950 · Cited by 878
Cited by
Metal Resistance and Its Association With Antibiotic Resistance
Pal, C., Asiani, K., Arya, S., Rensing, C., Stekel, D. J., Larsson, D. G. J., & Hobman, J. L. (2017) · Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2017.02.001 · Cited by 438
Sabri, N. A., Schmitt, H., Van der Zaan, B., Gerritsen, H. W., Zuidema, T., Rijnaarts, H. H. M., & Langenhoff, A. A. M. (2020) · Journal of Environmental Chemical Engineering · doi:10.1016/j.jece.2018.03.004 · Cited by 373
Henriksson, P. J. G., Rico, A., Troell, M., Klinger, D. H., Buschmann, A. H., Saksida, S., Chadag, M. V., & Zhang, W. (2018) · Sustainability Science · doi:10.1007/s11625-017-0511-8 · Cited by 266
Metadata
- Authors
- Hatosy, S. M., & Martiny, A. C.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2015-11
- Volume
- 81
- Issue
- 21
- Pages
- 7593-7599
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2150547022
- Cited by
- 249
- References
- 4
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
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