Structural and Molecular Basis of the Role of Starch and Sucrose in Streptococcus mutans Biofilm Development
Open accessAbstract
The interaction of sucrose and starch with bacterial glucosyltransferases and human salivary amylase may enhance the pathogenic potential of Streptococcus mutans within biofilms by influencing the structural organization of the extracellular matrix and modulating the expression of genes involved in exopolysaccharide synthesis and specific sugar transport and two-component systems.
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Saccharolytic bacteria include Streptococcus, Actinomyces, and Veillonella, which have the unique ability to degrade carbohydrates via the Embden-Meyerhof-Pernas pathway, producing acidic by-products including lactate, acetate, ethanol, and formate.
“The saccharolytic bacteria include Streptococcus, Actinomyces, and Veillonella, which have the unique ability to degrade carbohydrates via the Embden−Meyerhof−Pernas pathway, producing acidic by-products including lactate, acetate, ethanol, and formate [1,82].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [82]
Saccharolytic bacteria, including Streptococcus, Actinomyces, and Veillonella species, degrade carbohydrates via Embden-Meyerhof-Parnas pathways to produce acidic by-products including lactate, acetate, ethanol, and formate, which cause demineralization of dental enamel and development of carious lesions.
“Saccharolytic bacteria, including Streptococcus, Actinomyces, and Veillonella species, degrade carbohydrates via the Embden‐Meyerhof‐Parnas pathways to produce acidic by‐products, including lactate, acetate, ethanol, and formate, which cause demineralization of dental enamel and the development of carious lesions.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [286]
Carbohydrate use by S mutans is a well-recognized feature in the pathogenicity of dental caries.
“Carbohydrate use by S mutans is a well‐recognized feature in the pathogenicity of dental caries.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [286]
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References 39 · Cited by 154
- Authors
- Klein, M. I., Duarte, S., Xiao, J., Mitra, S., Foster, T. H., & Koo, H.
- Affiliations
- University of Rochester Medicine (US)
- Eastman Department of Dentistry and Center for Oral Biology
- University of Rochester (US)
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2009-02
- Volume
- 75
- Issue
- 3
- Pages
- 837-841
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC2632160
- OpenAlex
- W2053959757
- Cited by
- 154
- References
- 39
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 10 · 2023: 10 · 2022: 9 · 2021: 15 · 2020: 10 · 2019: 10 · 2018: 10 · 2017: 11 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy (DE-FG09-93ER-20097)
- University of Rochester
- Danmarks Tekniske Universitet
- National Institutes of Health (DE-FG09-93ER-20097)
- National Cancer Institute (R01CA068409, CA68409)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Streptococcus mutans, biofilm growth, starch, sucrose, glucosyltransferase, salivary amylase, extracellular matrix, exopolysaccharide biosynthesis, sugar transport, two-component systems, dental caries
- MeSH terms
- Amylases, Glucosyltransferases, Humans, Protein Binding, Saliva, Starch, Streptococcus mutans, Sucrose, Biofilms
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