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Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N -Acyl Cyclopentylamides
Open accessAbstract
N -Octanoyl cyclopentylamide (C8-CPA) was found to moderately inhibit quorum sensing in Pseudomonas aeruginosa PAO1. To obtain more powerful inhibitors, a series of structural analogs of C8-CPA were synthesized and examined for their ability to inhibit quorum sensing in P. aeruginosa PAO1. The lasB - lacZ and rhlA - lacZ reporter assays revealed that the chain length and the ring structure were critical for C8-CPA analogs to inhibit quorum sensing. N -Decanoyl cyclopentylamide (C10-CPA) was found to be the strongest inhibitor, and its concentrations required for half-maximal inhibition for lasB - lacZ and rhlA - lacZ expression were 80 and 90 μM, respectively. C10-CPA also inhibited production of virulence factors, including elastase, pyocyanin, and rhamnolipid, and biofilm formation without affecting growth of P. aeruginosa PAO1. C10-CPA inhibited induction of both lasI - lacZ by N -(3-oxododecanoyl)- l -homoserine lactone (PAI1) and rhlA - lacZ by N -butanoyl- l -homoserine lactone (PAI2) in the lasI rhlI mutant of P. aeruginosa PAO1, indicating that C10-CPA interferes with the las and rhl quorum-sensing systems via inhibiting interaction between their response regulators (LasR and RhlR) and autoinducers.
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Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Cited by
Quorum sensing signal-response systems in Gram-negative bacteria
Papenfort, K., & Bassler, B. L. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.89 · Cited by 2,256
Targeting virulence: can we make evolution-proof drugs?
Allen, R. C., Popat, R., Diggle, S. P., & Brown, S. P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3232 · Cited by 532
Mini-review: quorum sensing in the marine environment and its relationship to biofouling
Dobretsov, S., Teplitski, M., & Paul, V. (2009) · Biofouling · doi:10.1080/08927010902853516 · Cited by 388
Small molecule control of bacterial biofilms
Worthington, R. J., Richards, J. J., & Melander, C. (2012) · Organic & Biomolecular Chemistry · doi:10.1039/c2ob25835h · Cited by 299
Vandeputte, O. M., Kiendrebeogo, M., Rasamiravaka, T., Stévigny, C., Duez, P., Rajaonson, S., Diallo, B., Mol, A., Baucher, M., & El Jaziri, M. (2011) · Microbiology · doi:10.1099/mic.0.049338-0 · Cited by 293
Metadata
- Authors
- Ishida, T., Ikeda, T., Takiguchi, N., Kuroda, A., Ohtake, H., & Kato, J.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2007-05-15
- Volume
- 73
- Issue
- 10
- Pages
- 3183-3188
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2138139413
- Cited by
- 193
- References
- 1
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Ishida, T., Ikeda, T., Takiguchi, N., Kuroda, A., Ohtake, H., & Kato, J. (2007). Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N -Acyl Cyclopentylamides. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.02233-06
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