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Evidence for a cytoplasmic pathway of oxalate biosynthesis in Aspergillus niger
Open accessAbstract
Oxalate accumulation of up to 8 g/liter was induced in Aspergillus niger by shifting the pH from 6 to 8. This required the presence of Pi and a nitrogen source and was inhibited by the protein synthesis inhibitor cycloheximide. Exogenously added 14CO2 was not incorporated into oxalate, but was incorporated into acetate and malate, thus indicating the biosynthesis of oxalate by hydrolytic cleavage of oxaloacetate. Inhibition of mitochondrial citrate metabolism by fluorocitrate did not significantly decrease the oxalate yield. The putative enzyme that was responsible for this was oxaloacetate hydrolase (EC 3.7.1.1), which was induced de novo during the pH shift. Subcellular fractionation of oxalic acid-forming mycelia of A. niger showed that this enzyme is located in the cytoplasm of A. niger. The results are consistent with a cytoplasmic pathway of oxalate formation which does not involve the tricarboxylic acid cycle.
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Cited by
Papagianni, M. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2007.01.002 · Cited by 517
Paulista, L. O., Boaventura, R. A. R., Vilar, V. J. P., Pinheiro, A. L. N., & Martins, R. J. E. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06748-w · Cited by 20
Metadata
- Authors
- Kubicek, C. P., Schreferl-Kunar, G., Wöhrer, W., & Röhr, M.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1988-03
- Volume
- 54
- Issue
- 3
- Pages
- 633-637
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W1910101287
- Cited by
- 171
- References
- 0
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Evidence for a cytoplasmic pathway of oxalate biosynthesis in Aspergillus niger. https://app.cochat.ai/papers/10.1128/aem.54.3.633-637.1988
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- Kubicek, C. P., Schreferl-Kunar, G., Wöhrer, W., & Röhr, M. (1988). Evidence for a cytoplasmic pathway of oxalate biosynthesis in Aspergillus niger. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.54.3.633-637.1988
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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