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Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand
Open accessAbstract
A clonal isolate, termed L575, of the filamentous brackish-water cyanobacterium Nodularia spumigena Mertens emend. was found to produce a potent hepatotoxic peptide (50% lethal intraperitoneal dose for the mouse, 60 micrograms/kg) with chemical and toxicological properties similar to those of the hepatotoxic heptapeptides produced by other freshwater planktonic cyanobacteria. The isolate was made from a water sample collected in Lake Ellesmere, New Zealand, in 1980. The toxin, isolated and purified by high-performance liquid chromatography (HPLC) and analyzed by HPLC amino acid analysis, contained glutamic acid, beta-methyla-spartic acid, and arginine units in equivalent amounts. The fast-atom-bombardment mass spectrum of the toxin indicated the molecular weight to be 824. Batch cultures of strain L575 showed that the toxin content varied between 1.96 and 2.99 mg/g of cells and that a positive correlation between toxin content and chlorophyll a, but not biomass, was present.
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Citations
Cited by
The rise of harmful cyanobacteria blooms: the potential roles of eutrophication and climate change
O’Neil, J. M., Davis, T. W., Burford, M. A., & Gobler, C. J. (2012) · Harmful Algae · doi:10.1016/j.hal.2011.10.027 · Cited by 2,225
Cyanobacteria secondary metabolites—the cyanotoxins
Carmichael, W. W. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb01858.x · Cited by 1,457
Self-citationMarine cyanobacteria—a prolific source of natural products
Burja, A. M., Banaigs, B., Abou-Mansour, E., Grant Burgess, J., & Wright, P. C. (2001) · Tetrahedron · doi:10.1016/s0040-4020(01)00931-0 · Cited by 841
Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity
Yoshizawa, S., Matsushima, R., Watanabe, M. F., Harada, K.-I., Ichihara, A., Carmichael, W. W., & Fujiki, H. (1990) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01637082 · Cited by 578
Self-citationDeMott, W. R., Zhang, Q., & Carmichael, W. W. (1991) · Limnology and Oceanography · doi:10.4319/lo.1991.36.7.1346 · Cited by 481
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Metadata
- Authors
- Carmichael, W. W., Eschedor, J. T., Patterson, G. M., & Moore, R. E.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1988-09
- Volume
- 54
- Issue
- 9
- Pages
- 2257-2263
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W1798051273
- Cited by
- 161
- References
- 0
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand. https://app.cochat.ai/papers/10.1128/aem.54.9.2257-2263.1988
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- Carmichael, W. W., Eschedor, J. T., Patterson, G. M., & Moore, R. E. (1988). Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.54.9.2257-2263.1988
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