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C-ring cleavage of flavonoids by human intestinal bacteria
Open accessAbstract
Four hitherto undescribed Clostridium strains capable of cleaving the C ring of quercetin, kaempferol, and naringenin at C-3-C-4 were isolated from the fecal flora of humans. None of the strains cleaved catechin. C-ring fission occurred when the substrate was either in solution or in suspension. Mixed cultures of flavonoid-hydrolyzing bacteria, flavonoid-cleaving bacteria, and Escherichia coli, which was used to provide the anaerobic environment, rapidly metabolized rutin to 3,4-dihydroxyphenylacetic acid, indicating that the intestinal half-life of the biologically active aglycone is short. The cleaving strains shared many phenotypic characteristics, including their inability to ferment sugars, but they differed sufficiently to indicate that they represent different species.
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Citations
Cited by
Role of the normal gut microbiota
Jandhyala, S. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8787 · Cited by 3,001
The biochemistry and medical significance of the flavonoids
Havsteen, B. H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00298-x · Cited by 2,672
Antimicrobial properties of tannins
Scalbert, A. (1991) · Phytochemistry · doi:10.1016/0031-9422(91)83426-l · Cited by 2,321
Interaction between Phenolics and Gut Microbiota: Role in Human Health
Selma, M. V., Espín, J. C., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902107d · Cited by 1,324
In vitro antioxidant properties of rutin
Yang, J., Guo, J., & Yuan, J. (2008) · LWT - Food Science and Technology · doi:10.1016/j.lwt.2007.06.010 · Cited by 829
Metadata
- Authors
- Winter, J., Moore, L. H., Dowell, V. R., & Bokkenheuser, V. D.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1989-05
- Volume
- 55
- Issue
- 5
- Pages
- 1203-1208
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W1567600191
- Cited by
- 248
- References
- 0
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Winter, J., Moore, L. H., Dowell, V. R., & Bokkenheuser, V. D. (1989). C-ring cleavage of flavonoids by human intestinal bacteria. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.55.5.1203-1208.1989
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