THE CALCULATION OF MICROBIAL ASSAYS
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In drug combination studies for cancer, Loewe additivity is appropriate when the drugs target the same pathways, whereas Bliss independence is more appropriate when two drugs are mutually nonexclusive, i.e. each targets a different signaling pathway.
“In drug combination studies for cancer, the Loewe additivity is appropriate when the drugs target same pathways. In contrast, the Bliss independence principle is more appropriate when two drugs are mutually nonexclusive, i.e. when each target a different signaling pathway.”
From Evaluation of Drug Combination Effect Using a Bliss Independence Dose–Response Surface Model (2018) · cites this paper as Bliss 1956
Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
No references could be resolved yet.
Research works printed but not linked: 3
- BLiss, C. I. 1952 The statistics of bioassay with special reference to the vitamins. Academic Press, Inc., New York, N. Y.
- BLiss, C.I. 1956a Confidence limits for measuring the precision of bioassays. Biometrics, 12, in press.
- BLiss, C. I. 1957 Bioassay from a parabola. Biometrics, 13, in press.
Cited by
Sorted by citations
Systems biology and combination therapy in the quest for clinical efficacy
Fitzgerald, J. B., Schoeberl, B., Nielsen, U. B., & Sorger, P. K. (2006) · Nature Chemical Biology · doi:10.1038/nchembio817 · Cited by 570 · see citing works
Evaluation of Drug Combination Effect Using a Bliss Independence Dose–Response Surface Model
Liu, Q., Yin, X., Languino, L. R., & Altieri, D. C. (2018) · Statistics in Biopharmaceutical Research · doi:10.1080/19466315.2018.1437071 · Cited by 216 · see citing works
EWS/FLI confers tumor cell synthetic lethality to CDK12 inhibition in Ewing sarcoma
Iniguez, A. B., Stolte, B., Wang, E. J., Conway, A. S., Alexe, G., Dharia, N. V., Kwiatkowski, N., Zhang, T., Abraham, B. J., Mora, J., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.12.009 · Cited by 173 · see citing works
Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria
García-Heredia, A., Pohane, A. A., Melzer, E. S., Carr, C. R., Fiolek, T. J., Rundell, S. R., Lim, H. C., Wagner, J. C., Morita, Y. S., Swarts, B. M., et al. (2018) · eLife · doi:10.7554/elife.37243 · Cited by 115 · see citing works
Combination therapeutics in complex diseases
He, B., Lu, C., Zheng, G., He, X., Wang, M., Chen, G., Zhang, G., & Lu, A. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12930 · Cited by 112 · see citing works
Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking
Zhao, M., Zhang, F., Zarnowski, R., Barns, K., Jones, R., Fossen, J., Sanchez, H., Rajski, S. R., Audhya, A., Bugni, T. S., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145123 · Cited by 62 · see citing works
A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation
Ge, A. Y., Arab, A., Dai, R., Navickas, A., Fish, L., Garcia, K., Asgharian, H., Goudreau, J., Lee, S., Keenan, K., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-77314-9 · Cited by 4 · see citing works
- Authors
- Bliss, C. I.
- Affiliations
- Yale University (US)
- Corresponding author
- Bliss, C. I.
- Venue
- Bacteriological Reviews
- Publisher
- American Society for Microbiology
- Published
- 1956-12
- Volume
- 20
- Issue
- 4
- Pages
- 243-258
- ISSN
- 0005-3678 (ISSN-L)
- PMC
- PMC180866
- OpenAlex
- W2195725578
- Cited by
- 163
- References
- 0
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 11 · 2023: 25 · 2022: 11 · 2021: 11 · 2020: 12 · 2019: 3 · 2018: 11 · 2017: 6 · 2016: 10 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 7
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Bacteriological Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › thermodynamics and calorimetric analyses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- microbiological assay, bacterial growth kinetics
- MeSH terms
- Bacteriology, Biological Assay
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
