Rapid growth and metabolism of uropathogenic Escherichia coli in relation to urine composition
Open accessAbstract
express transporters for peptides, amino acids, carbohydrates, and iron and genes associated with nitrogen limitation, amino acid synthesis, nucleotide synthesis, and nucleotide salvage. Mouse models confirm the requirement for many, but not all, of these genes. Laboratory evolution studies suggest that rapid nutrient uptake without metabolic rewiring is sufficient to account for rapid growth. Proteins and pathways required for rapid growth should be considered potential targets for alternate or adjunct therapies.
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During UPEC infection, bacteria move from a relatively high-iron environment (about 10^-6 M in urine) to an intracellular iron-starvation environment.
“During this process, bacteria move from an environment with a relatively high-iron concentration (about 10 −6 M in the urine) to an intracellular, iron-starvation environment ( 12 , 34–36 ).”
From YdiV regulates Escherichia coli ferric uptake by manipulating the DNA-binding ability of Fur in a SlyD-dependent manner (2020) · cites this paper as [36]
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References 124 · Cited by 85
- Authors
- Reitzer, L., & Zimmern, P.
- Affiliations
- The University of Texas at Dallas (US)
- The University of Texas Southwestern Medical Center (US)
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2019-12-18
- Volume
- 33
- Issue
- 1
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- PMC
- PMC6927312
- OpenAlex
- W2980400722
- Cited by
- 85
- References
- 124
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 18 · 2023: 18 · 2022: 17 · 2021: 9 · 2020: 7
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Microbiology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Keywords
- uropathogenic Escherichia coli, bacterial growth rate, bacterial metabolism, urine composition, nutrient uptake, iron transport, amino acid transport, nitrogen limitation, nucleotide synthesis, nucleotide salvage, amino acid synthesis, experimental evolution, mouse model, antimicrobial drug targets
- MeSH terms
- Animals, Bacteriuria, Disease Susceptibility, Energy Metabolism, Escherichia coli Infections, Humans, Urinary Tract Infections, Genetic Variation, Virulence, Biomarkers, Molecular Diagnostic Techniques, Virulence Factors, Uropathogenic Escherichia coli
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