The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections
Open accessAbstract
SUMMARY: The acyclic nucleoside phosphonates HPMPC (cidofovir), PMEA (adefovir), and PMPA (tenofovir) have proved to be effective in vitro (cell culture systems) and in vivo (animal models and clinical studies) against a wide variety of DNA virus and retrovirus infections: cidofovir against herpesvirus (herpes simplex virus types 1 and 2 varicella-zoster virus, cytomegalovirus [CMV], Epstein-Barr virus, and human herpesviruses 6, 7, and 8), polyomavirus, papillomavirus, adenovirus, and poxvirus (variola virus, cowpox virus, vaccinia virus, molluscum contagiosum virus, and orf virus) infections; adefovir against herpesvirus, hepadnavirus (human hepatitis B virus), and retrovirus (human immunodeficiency virus types 1 [HIV-1] and 2 [HIV-2], simian immunodeficiency virus, and feline immunodeficiency virus) infections; and tenofovir against both hepadnavirus and retrovirus infections. Cidofovir (Vistide) has been officially approved for the treatment of CMV retinitis in AIDS patients, tenofovir disoproxil fumarate (Viread) has been approved for the treatment of HIV infections (i.e., AIDS), and adefovir dipivoxil (Hepsera) has been approved for the treatment of chronic hepatitis B. Nephrotoxicity is the dose-limiting side effect for cidofovir (Vistide) when used intravenously (5 mg/kg); no toxic side effects have been described for adefovir dipivoxil and tenofovir disoproxil fumarate, at the approved doses (Hepsera at 10 mg orally daily and Viread at 300 mg orally daily).
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Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Positive Chronic Hepatitis B
Marcellin, P., Chang, T.-T., Lim, S. G., Tong, M. J., Sievert, W., Shiffman, M. L., Jeffers, L., Goodman, Z., Wulfsohn, M. S., Xiong, S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020681 · Cited by 1,336
Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Negative Chronic Hepatitis B
Hadziyannis, S. J., Tassopoulos, N. C., Heathcote, E. J., Chang, T.-T., Kitis, G., Rizzetto, M., Marcellin, P., Lim, S. G., Goodman, Z., Wulfsohn, M. S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021812 · Cited by 995
Prevention of SIV Infection in Macaques by ( R )-9-(2-Phosphonylmethoxypropyl)adenine
Tsai, C.-C., Follis, K. E., Sabo, A., Beck, T. W., Grant, R. F., Bischofberger, N., Benveniste, R. E., & Black, R. (1995) · Science · doi:10.1126/science.270.5239.1197 · Cited by 563
Birkus, G., Hitchcock, M. J. M., & Cihlar, T. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.3.716-723.2002 · Cited by 441
Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase
Johnson, A. A., Ray, A. S., Hanes, J., Suo, Z., Colacino, J. M., Anderson, K. S., & Johnson, K. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106743200 · Cited by 403
Lalezari, J. P., Stagg, R. J., Kuppermann, B. D., Holland, G. N., Kramer, F., Ives, D. V., Youle, M., Robinson, M. R., Drew, W. L., & Jaffe, H. S. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-4-199702150-00001 · Cited by 372
Cihlar, T., Lin, D. C., Pritchard, J. B., Fuller, M. D., Mendel, D. B., & Sweet, D. H. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23084-4 · Cited by 345
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Clinical Pharmacokinetics of the Antiviral Nucleotide Analogues Cidofovir and Adefovir
Cundy, K. C. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199936020-00004 · Cited by 303
Cidofovir in the treatment of poxvirus infections
De Clercq, E. (2002) · Antiviral Research · doi:10.1016/s0166-3542(02)00008-6 · Cited by 283
Self-citation
Cited by
Acyclic nucleoside phosphonates: a key class of antiviral drugs
Clercq, E. D., & Holý, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1877 · Cited by 688
Topical formulation of self-assembled antiviral prodrug nanomicelles for targeted retinal delivery
Mandal, A., Cholkar, K., Khurana, V., Shah, A., Agrahari, V., Bisht, R., Pal, D., & Mitra, A. K. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00128 · Cited by 60
Balestrieri, E., Sciortino, M. T., Mastino, A., & Macchi, B. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2005.09.001 · Cited by 19
Metadata
- Authors
- De Clercq, E.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2003-10
- Volume
- 16
- Issue
- 4
- Pages
- 569-596
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2168652503
- Cited by
- 369
- References
- 66
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- green
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- De Clercq, E. (2003). Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.16.4.569-596.2003
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